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research-articleAsian Journal of Biological and Life SciencesVol. 14 | Issue 2 | 2014 | pp. 426–433Open access
Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK)
- 1,
- 2,
- 3,
- 1
- 1 Department of Siddhar Yoga Maruthuvam, Government Siddha Medical College, Chennai, Tamil Nadu, INDIA.
- 2 Department of Gunapadam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.
- 3 Department of Nanju Maruthuvam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.
Published in Asian Journal of Biological and Life Sciences
Correspondence: Dr. Medini Elanchezhian PG Scholar, Department of Siddhar Yoga Maruthuvam, Government Siddha Medical College, Chennai-600106, Tamil Nadu, INDIA. Email: drmedini22@gmail.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2014
- Received:
- Feb 7, 2025
- Accepted:
- Jun 24, 2025
How to cite
Elanchezhian, M., Ramasamy, S., Balasubramani, A., & Chidambaram, L. (2014). Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK). Asian Journal of Biological and Life Sciences, 14(2), 426–433. https://doi.org/10.5530/ajbls.20251508
Abstract
Background: Docking studies of Sittramutti khirutham (SK) compounds against HCV RdRp (PDB:3MWV) were performed to evaluate inhibitory potential. Results: Compounds such as Curcumin, Maslinic acid, Arjungenin, Andrograpanin, Andrographolide, and Epiafzelechin showed 2–3 interactions with active residues, indicating promising RdRp inhibition. Conclusion: Docking suggests SK compounds may inhibit HCV RdRp and warrant further pharmacological validation.
Keywords
Article metadata
| Title | Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK) |
|---|---|
| Authors | Medini Elanchezhian; Suresh Ramasamy; Abarna Balasubramani; Lakshmanaraj Chidambaram |
| Affiliations | Department of Siddhar Yoga Maruthuvam, Government Siddha Medical College, Chennai, Tamil Nadu, INDIA.; Department of Gunapadam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.; Department of Nanju Maruthuvam, National Institute Siddha, Chennai, Tamil Nadu, INDIA. |
| Corresponding author | drmedini22@gmail.com |
| Journal | Asian Journal of Biological and Life Sciences |
| Volume / Issue | Vol. 14, Issue 2 (2014) |
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