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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 46 | Issue 2 | 2012 | pp. 185–191Open access
Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues
- 1*,
- 2,
- 1,
- 1
- 1 Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara Mandya-571448, Karnataka, India.
- 2 Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, KM Doddi, Mandya.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: N.K. Sathish
Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara Mandya-571448, Karnataka, India.
Email: nksathish76@gmail.com
Copyright: © 2012 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 14, 2012
- Received:
- Feb 10, 2011
- Accepted:
- Nov 24, 2011
- DOI:
- 10.5530/xxxxxxxxx
How to cite
Sathish, N., Shahensha, S., Ali, M. I., & Chethan, I. (2012). Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues. Indian Journal of Pharmaceutical Education and Research, 46(2), 185–191. https://doi.org/10.5530/xxxxxxxxx
Abstract
Some new 2-[(E)-2-(substituted phenyl) ethenyl]-3-(2/4methyl phenyl) quinazolin-4(3H)-ones (Q1a-f Q2a-f have been synthesized from 3-(2- methyl phenyl) quinazolin-4(3H)-one (Q1) and 3-(4-methyl phenyl) quinazolin-4(3H)-one (Q2) by introducing different aromatic aldehydes. The synthesized compounds have been characterized by IR, 1H NMR, 13C NMR and Mass spectral techniques and screened for anti-inflammatory activity by using carrageenan induced rat paw edema method. Compounds Q1a, Q1e, Q1f and Q2f showed potent activity when compared to diclofenac sodium as standard. Examination of the relationship between lipophilicity and anti-inflammatory activity of quinazolines showed poor correlation.
Keywords
Subject
Article metadata
| Title | Synthesis, Characterisation and Anti-inflammatory Activity of some Novel Quinazolin-4-(3h)-one Analogues |
|---|---|
| Authors | N.K. Sathish; S Shahensha; M Irfan Ali; I.A. Chethan |
| Affiliations | Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara Mandya-571448, Karnataka, India.; Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, KM Doddi, Mandya. |
| Corresponding author | nksathish76@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 46, Issue 2 (2012) |
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