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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 46 | Issue 3 | 2012 | pp. 206–210Open access
Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones
- 1,
- 1*,
- 1,
- 1
- 1 Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: B. Jayalakshmi
Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.
Email: bjayavasan@gmail.com
Copyright: © 2012 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 18, 2012
- Received:
- May 3, 2011
- Accepted:
- Dec 17, 2011
- DOI:
- 10.5530/xxxxxxxxx
How to cite
Aslak, C., Jayalakshmi, B., Balasubramaniam, A., & Senthilkumar, N. (2012). Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones. Indian Journal of Pharmaceutical Education and Research, 46(3), 206–210. https://doi.org/10.5530/xxxxxxxxx
Abstract
New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparatively more active.
Keywords
Subject
Article metadata
| Title | Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones |
|---|---|
| Authors | C.M Aslak; B. Jayalakshmi; A. Balasubramaniam; N. Senthilkumar |
| Affiliations | Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India. |
| Corresponding author | bjayavasan@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 46, Issue 3 (2012) |
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