Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation

Kulkarni, Preeti; Desai, Sonal; Tatke, Pratima; Ghule, T. P.; Chavan, C.D.; Bhate, V. R.

Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 47 | Issue 2 | 2013 | pp. 183–187Open access

Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation

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¹ C. U. Shah College Of Pharmacy, S. N. D. T. Women's University, Santacruz (W), Mumbai-400 049, India.
² Analytical Solutions, R-610, Rabale, M. I. D. C., Mumbai-400 701, India.

Correspondence: Pratima Tatke
C. U. Shah College Of Pharmacy, S. N. D. T. Women's University, Santacruz (W), Mumbai-400 049, India.
Email: patatke@gmail.com

Published:: Sep 20, 2013
Received:: Jun 28, 2012
Accepted:: Mar 28, 2013

How to cite

Kulkarni, P., Desai, S., Tatke, P., Ghule, T. P., Chavan, C., & Bhate, V. R. (2013). Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation. Indian Journal of Pharmaceutical Education and Research, 47(2), 183–187.

Abstract

The present study aims at development of method for simultaneous estimation of chloride and citrate in oral rehydration salt (ORS) by ion chromatography and its validation. The estimation was carried out with a step change gradient mode by altering concentrations of NaOH as an eluent, an anion exchange column IonPac AS11 analytical column, guard column AG11 and conductivity detector. The suppressor used was used as ASRS ULTRA. The developed method was validated as per ICH guidelines for various parameters. The method is useful for determining the contents of chloride and citrate in single run from ORS.

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Article metadata

Title	Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation
Authors	Preeti Kulkarni; Sonal Desai; Pratima Tatke; T. P. Ghule; C.D. Chavan; V. R. Bhate
Affiliations	C. U. Shah College Of Pharmacy, S. N. D. T. Women's University, Santacruz (W), Mumbai-400 049, India.; Analytical Solutions, R-610, Rabale, M. I. D. C., Mumbai-400 701, India.
Corresponding author	patatke@gmail.com
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 47, Issue 2 (2013)