Open access · Peer reviewed · No APCs
Pharmaceutical ResearchIndian Journal of Pharmaceutical Education and ResearchVol. 48 | Issue 1 | 2014 | pp. 39–48Open access
The Chemopreventive Effect of Nigella Sativa on 1,2-dimethylhydrazine-induced Colon Tumor
- 1*,
- 2,
- 3,
- 4,
- 5,
- 5
- 1 Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
- 2 Nuclear Fuel Cycle research school, Nuclear Science and Technology Research Institute, Tehran, I.R. Iran.
- 3 Department of pathobiology, Faculty of veterinary medicine, Garmsar Branch, Islamic Azad University, Garmsar-Iran.
- 4 Young Researchers Club, Garmsar Branch, Islamic Azad University, Garmsar, Iran.
- 5 Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Dadkhah A
Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
Email: Dadkhah_bio@yahoo.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 30, 2014
- DOI:
- 10.5530/ijper.48.1.7
How to cite
A, D., F, F., M, M., A, J., F, B., & Z, G. (2014). The Chemopreventive Effect of Nigella Sativa on 1,2-dimethylhydrazine-induced Colon Tumor. Indian Journal of Pharmaceutical Education and Research, 48(1), 39–48. https://doi.org/10.5530/ijper.48.1.7
Abstract
In this study, the chemopreventive efficacy of Nigella sativa seed powder as an important chemopreventive herb on the formation of colon tumor has been examined through measuring the levels of hepatic oxidative stress and metabolizing enzymes in 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats. Male Wistar rats were divided into 6 groups as untreated control, Sham, DMH (30mg/kg b.w) received carcinogen via subcutaneously (s.c) injection once a week for 18 weeks and treatment groups received diet containing Nigella sativa (2 and 4%) until the end of whole experimental period of 6 months. It is indicated that Nigella sativa seed powder could prevent colon tumor formation by modulating the activities of hepatic detoxification enzymes, GST and CYP450 whereas antioxidant statues are not affected. The data was confirmed by histopathological findings It is obvious that one of the mechanisms of chemoprevention of colon tumorigenesis by Nigella sativa seed powder may be the enhancement of carcinogen detoxification but not antioxidant system in the liver.
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Article metadata
| Title | The Chemopreventive Effect of Nigella Sativa on 1,2-dimethylhydrazine-induced Colon Tumor |
|---|---|
| Authors | Dadkhah A; Fatemi F; Malayeri M; Jahanbani A; Batebi F; Ghorbanpour Z |
| Affiliations | Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.; Nuclear Fuel Cycle research school, Nuclear Science and Technology Research Institute, Tehran, I.R. Iran.; Department of pathobiology, Faculty of veterinary medicine, Garmsar Branch, Islamic Azad University, Garmsar-Iran.; Young Researchers Club, Garmsar Branch, Islamic Azad University, Garmsar, Iran.; Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran. |
| Corresponding author | Dadkhah_bio@yahoo.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 48, Issue 1 (2014) |
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