Formulation and Evaluation of Controlled Release Gastro-Retentive In situ Gel for Diltiazem Hydrochloride

  In present study is to develop Gastro-Retentive controlled release in situ gel using natural and synthetic polymers. Gastro-retentive controlled release in situ gels were prepared to controlled drug delivery, to improve bioavailability, stability, reducing side effects. For the present work 32 factorial designs was selected. The two independent variables were selected sodium alginate (X1 ) and ratio of polymers HPMC K4M: Gellum Gum (X2 ) combined concentration of HPMC K4M and Gellum Gum was kept constant i.e. 2% and nine formulations were formulated as per experimental design, From evaluation of in situ gel formulation for factorial batches, formulation HPGG7 has show good gel strength, lag time (98 ± 0.57) sec, pH value (7.4 ± 0.20), drug contain (99.92 ± 0.04)%, viscosity before and after gel (32715 ± 1.15) and (39850 ± 1.73)cp respectively, total floating time more than 24 hours and also have good controlled release behaviour as it retard drug release up to (79.2 ± 0.50) % . Formulated in situ gel were stable at the selected temperature and humidity in storage for 3 month. Hence, from above it was concluded that formulation, in situ gel formulation HPPGG7 was containing sodium alginate (1.5%)w/v, HPMC K4M (0.5%)w/v, Gellum gum (1.5%)w/v, which could be most promising gastro-retentive in situ gel formulation. It was concluded that the prepared controlled release in situ gel of Diltiazem Hydrochloride may prove to be potential candidate for safe and effective controlled drug delivery for extended period of time.