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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 51 | Issue 2s | 2017 | pp. s79–s90Open access
Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent
- 1,2,
- 1,
- 2,3,
- 1,
- 4,5,
- 1,4*,
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- 1 Laboratory of Organic Physical and Macromolecular Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.
- 2 Department of Pharmacy, Faculty of Medicine Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.
- 3 Hospitalo-Universitary Center C.H.U of Sidi Bel-Abbes, 22 000 ALGÉRIA.
- 4 Department of Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.
- 5 Laboratory of Innovation and BioperformanceAnalyse -LIAB, Polytechnic School, University of Montreal Quebec, CANADA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Nafa Chafi
Laboratory of Organic Physical and Macromolecular Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.; Department of Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.
Email: nafachafi@yahoo.com
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 14, 2017
- Received:
- Mar 21, 2016
- Accepted:
- Nov 17, 2016
How to cite
Chirani, S., Lebig, M. O., Bouameur, S., Mouffok, M., Chirani, N., Chafi, N., & Guemra, K. (2017). Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent. Indian Journal of Pharmaceutical Education and Research, 51(2s), s79–s90. https://doi.org/10.5530/ijper.51.2s.53
Abstract
Introduction: The present paper provides details of preparation of hardcapsules based on microspheres containing 2-aminothiazole as an antithyroidian agent and synthesized poly(butylsuccinate) (PBS) or ethylcellulose(EC10) as biodegradable matrices as well as the study of the drug delivery. Methods: A disintegration tests of these gelatinous capsules were done. The biodegradable synthesized polyester was characterized by infrared spectroscopy, nuclear magnetic resonance (mono and bidimentional H1NMR, 13CNMR) and by Differential Scanning Calorimetry (DSC). A viscosimetric study has been done in order to evaluate viscosimetric PBS's weight wich was calculated from Mark-Houwink equation. The microencapsulation of 2-aminothiazole was done using solvent evaporation technique. Results: Microspheres were spherical and the effects of varying emulsifiers and blades number on microspheres encapsulation efficiency were evaluated. A kinetic studies of releases of 2-aminothiazole in gastric pH were done in order to evaluate the best late effect and then the best formulation.
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Article metadata
| Title | Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent |
|---|---|
| Authors | Soumia Chirani; Mohamed Oussama Lebig; Sarah Bouameur; Meriyem Mouffok; Naziha Chirani; Nafa Chafi; Kaddour Guemra |
| Affiliations | Laboratory of Organic Physical and Macromolecular Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.; Department of Pharmacy, Faculty of Medicine Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.; Hospitalo-Universitary Center C.H.U of Sidi Bel-Abbes, 22 000 ALGÉRIA.; Department of Chemistry, Faculty of Exact Sciences, University DjillaliLiabes of SidiBel-Abbes, ALGERIA.; Laboratory of Innovation and BioperformanceAnalyse -LIAB, Polytechnic School, University of Montreal Quebec, CANADA. |
| Corresponding author | nafachafi@yahoo.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 51, Issue 2s (2017) |
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