Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 52 | Issue 1 | 2018 | pp. 71–77Open access
Solid State Characterization and Tableting Studies of Ethanol Based Cocrystals of Fenofibrate with Nicotinamide
- 1*,
- 2,
- 3,
- 4,
- 4,
- 1
- 1 Department of Pharmaceutics, Krishna Institute of Pharmacy of Krishna Institute of Medical Sciences Deemed University, Karad, INDIA.
- 2 Department of pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, INDIA.
- 3 Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, INDIA.
- 4 Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Amol Somanath Shete
Department of Pharmaceutics, Krishna Institute of Pharmacy of Krishna Institute of Medical Sciences Deemed University, Karad, INDIA.
Email: amol.shete@rediffmail.com
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 2, 2018
- Received:
- Jul 13, 2017
- Accepted:
- Jan 10, 2018
- DOI:
- 10.5530/ijper.52.1.8
How to cite
Shete, A. S., Khandagale, V. V., Murthy, S. M., Yadav, A. V., Sakhare, S. S., & Doijad, R. C. (2018). Solid State Characterization and Tableting Studies of Ethanol Based Cocrystals of Fenofibrate with Nicotinamide. Indian Journal of Pharmaceutical Education and Research, 52(1), 71–77. https://doi.org/10.5530/ijper.52.1.8
Abstract
Objectives: The pharmaceutical cocrystals can be defined as dissociable “API-excipient” molecular complexes or Co-crystals are solids that are crystalline materials composed of two or more molecules in the same crystal lattice as per U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) April 2013. The objectives of present investigation were to formulate cocrystals of fenofibrate with nicotinamide by solution cocrystallization technique. Methods: The cocrystals were prepared by solution cocrystallization technique by using ethanol as a solvent and nicotinamide as a coformer in the ratio of 1:1 & 1:2. The prepared cocrystals were evaluate for, solid state characterization by FTIR, PXRD, Raman spectroscopy and evaluated for tableting performance. Results: The formation of cocrystals has been confirmed by FTIR and Raman spectroscopy. The formulations 1:1 and 1:2 ratios showed better flow properties. The order of tableting performance 1:2 ratio cocrystals > 1:1 ratio cocrystals > Recrystallized nicotinamide > Nicotinamide >> Recrystallized Fenofibrate >> Fenofibrate. Conclusion: The cocrystals showed superior tableting performance. This might be due to the co-crystals, contains hydrogen-bonded two dimensional flat slip planes which exhibits higher plasticity.
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Article metadata
| Title | Solid State Characterization and Tableting Studies of Ethanol Based Cocrystals of Fenofibrate with Nicotinamide |
|---|---|
| Authors | Amol Somanath Shete; Vishwajeet V Khandagale; Srinivasa M Murthy; Adhikrao Vyankatrao Yadav; Sfurti Shamling Sakhare; Rajendra Chandrashekhar Doijad |
| Affiliations | Department of Pharmaceutics, Krishna Institute of Pharmacy of Krishna Institute of Medical Sciences Deemed University, Karad, INDIA.; Department of pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, INDIA.; Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, INDIA.; Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, INDIA. |
| Corresponding author | amol.shete@rediffmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 52, Issue 1 (2018) |
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