Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 52 | Issue 3 | 2018 | pp. 398–407Open access
Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp
- 1,
- 2*
- 1 Star “A” apartments, Bhagyanagar colony, Kukatpally, Hyderabad, Telangana 500072, INDIA.
- 2 Professor of Pharmaceutics, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: KV Ramana Murthy
Professor of Pharmaceutics, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, INDIA.
Email: sudhakarpharma@gmail.com
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 17, 2018
- Received:
- Sep 14, 2017
- Accepted:
- Nov 26, 2017
How to cite
Reddy, P. S., & Murthy, K. R. (2018). Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp. Indian Journal of Pharmaceutical Education and Research, 52(3), 398–407. https://doi.org/10.5530/ijper.52.3.46
Abstract
Introduction: The objective of the present formulation research is to deliver the drugs at a faster rate and to provide immediate onset of action in a shorter period of time with improved bioavailability. Materials and Methods: Ezetimibe, a gift sample from Lupin Ltd., Pune, Transcutol HP, a gift sample from Gattefosse India Pvt. Ltd., Goa., HPMC E5, HPMC E6, HPMC E15 are gift samples from Colorcon India Pvt. Ltd. Results and Discussion: Among prepared formulations coded E1 to E20, formulation E6 was shown promising results, hence further studies done without transcutol HP and documented clear results saying that, without transcutol HP has shown around 50% of drug even after 90 min of time, whereas within 10 min complete drug release observed with transcutol HP formulation. Conclusion: The study clearly indicated the influence of transcutol HP in enhancing the solubility of the poorly soluble drugs as the films made without transcutol HP failed to give the desired release characteristics within 10 min.
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Article metadata
| Title | Formulation and Evaluation of Oral Fast Dissolving Films of Poorly Soluble Drug Ezetimibe Using Transcutol Hp |
|---|---|
| Authors | Pondugula Sudhakara Reddy; KV Ramana Murthy |
| Affiliations | Star “A” apartments, Bhagyanagar colony, Kukatpally, Hyderabad, Telangana 500072, INDIA.; Professor of Pharmaceutics, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, INDIA. |
| Corresponding author | sudhakarpharma@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 52, Issue 3 (2018) |
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