Diosmin Phytosomes: Development, Optimization and Physicochemical Characterization

Background: Diosmin is a flavonoids glycoside that possesses different therapeutic activity include vascular-protecting agent used to help improving chronic venous insufficiency (CVI), haemorrhoids, etc. Diosmin is bioactive flavones constituent with wide range of biological activity. The poor solubility and dissolution rate limit its oral absorption and bioavailability. Aim: The aim of the present study is to develop diosmin - phospholipid complex (DN-PC) and characterized by physicochemical method. Method: DN-PC was prepared by refluxing followed by solvent evaporation technique in different ratios of Diosmin to Phosphatidylcholine. Physicochemical Characterization: DN-PC was characterised by various parameters like drug content, solubility studies, particle size determination, infrared absorption (FTIR), Differential scanning calorimetry (DSC), X-ray diffraction (XRD), Scanning electron microscopy (SEM), entrapment efficiency etc. Results: SEM and XRD revealed the reduction in crystallinity of diosmin in the phytosomes. FTIR and DSC confirm the formation of phyto-phospholipid complex. Conclusion: The results of the study revealed that the phospholipid complex may be considered as a promising drug delivery system that improves the absorption and bioavailability of plant constituents.