Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 52 | Issue 4 | 2018 | pp. s63–s70Open access
Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene
- 1*,
- 1,
- 1
- 1 Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, INDIA.
Email: mathrusri2000@ yahoo.com
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 20, 2018
- Received:
- Nov 28, 2017
- Accepted:
- May 17, 2018
How to cite
Annapurna, M. M., Venkatesh, B., & Teja, G. R. (2018). Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene. Indian Journal of Pharmaceutical Education and Research, 52(4), s63–s70. https://doi.org/10.5530/ijper.52.4s.77
Abstract
Introduction: Pterostilbene, a stilbenoid possess diversified pharmacological activities. In the present study, a stability-indicating liquid chromatographic method was proposed for the determination of Pterostilbene in pharmaceutically available formulations. Materials and Methods: The chromatographic separation was achieved on Phenomenex C8 type column as stationary phase. UV detection was carried out at 219 nm. Pterostilbene was subjected to various stress conditions such as acidic, alkaline, oxidative, thermal and photolytic degradations. Results:The drug was found to be sensitive towards acidic and alkaline stress conditions. The proposed method was validated as per the ICH guidelines and successfully applied to the available marketed formulations. Conclusion: The proposed method is selective, specific, robust and can be applied for the assay of pharmaceutical dosage forms.
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Article metadata
| Title | Development of a Validated Stability Indicating Liquid Chromatographic Method for the Determination of Pterostilbene |
|---|---|
| Authors | Mukthinuthalapati Mathrusri Annapurna; Bukkapatnam Venkatesh; Gunnam Ravi Teja |
| Affiliations | Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, Andhra Pradesh, INDIA. |
| Corresponding author | mathrusri2000@ yahoo.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 52, Issue 4 (2018) |
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