Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 53 | Issue 1 | 2019 | pp. 171–177Open access
Release of Doxorubicin’s Active Ingredient from the Hydrogels Derived from Acrylamide and their Biological Functions
- ,
- ,
- 2
- 1 Department of Biochemistry, Faculty Of Pharmacy, Sivas Cumhuriyet University, Sivas, TURKEY.
- 2 Erciyes University, Education Faculty Primary Education, Science Education Department, Kayseri, TURKEY.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Email: cozsoya@gmail.com
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 7, 2019
- Received:
- Nov 18, 2016
- Accepted:
- Jan 11, 2018
How to cite
Misir, S., Hepokur, C., & Kariper, I. A. (2019). Release of Doxorubicin’s Active Ingredient from the Hydrogels Derived from Acrylamide and their Biological Functions. Indian Journal of Pharmaceutical Education and Research, 53(1), 171–177. https://doi.org/10.5530/ijper.53.1.22
Abstract
Poly (HEMA/acrylamide/ methyl methacrylate) (PHAM) and Poly (Acrylamide/ methyl methacrylate)(PAM) polymers were synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate) (PAM) composite hydrogels were prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, and methacrylamide, with the presence of N,N’-methylenebisacrylamide. The characterization of the polymer was performed by FTIR analysis. Swelling and drug absorption properties of the polymers were analyzed in distilled water. Polymers’ toxic effects were investigated by XTT assay. It has been observed that the entire drug, which was added to the solution with 1 g of polymer, was absorbed for 3.5 h. The absorption of these polymers was found quite high. PHAM polymer showed >800% swelling and PAM polymer showed >600% at 600 min. PHAM polymer was less toxic than PAM polymer. These results, this new polymer is very suitable for the release of Doxorubicin drug.
Keywords
Subject
Article metadata
| Title | Release of Doxorubicin’s Active Ingredient from the Hydrogels Derived from Acrylamide and their Biological Functions |
|---|---|
| Authors | Sema Misir; Ceylan Hepokur; I. Afşin Kariper |
| Affiliations | Department of Biochemistry, Faculty Of Pharmacy, Sivas Cumhuriyet University, Sivas, TURKEY.; Erciyes University, Education Faculty Primary Education, Science Education Department, Kayseri, TURKEY. |
| Corresponding author | cozsoya@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 53, Issue 1 (2019) |
Also in this issue
- Professor Harkishan Singh- A Man with a Missionpp. 1–4
- Excipients: The Real Players behind Robust Formulationpp. 5–7
- Chemistry and Pharmacology of Flavonoids- A Reviewpp. 8–20
- Effect of Strategic Marketing on Sustainable Business Performance–A Study of Pharmaceutical Industries in Indiapp. 21–27
- Implementation of Innovative Learning Material to Improve Students Competence on Chemistrypp. 28–41
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026