Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization

Sreeharsha, Nagaraja; Hiremath, Jagadeesh G; Al-Dhubiab, Bandar E; Meravanige, Girish; Karnati, Ranjith Kumar; Attimarad, Mahesh; Nair, Anroop B; Venugopal, Katharigatta N; Morsy, Mohamed A; Pottathil, Shinu; Khan, Saleemmulla; Molugulu, Nagashekhara

doi:10.5530/ijper.54.3.135

Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 3 | 2020 | pp. 826–834Open access

Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization

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¹ Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
² Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
³ Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
⁴ Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.
⁵ Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
⁶ Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
⁷ School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.
⁸ Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.
⁹ Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
¹⁰ Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.

Correspondence: Nagaraja Sreeharsha
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
Email: sharsha@kfu.edu.sa

Published:: Aug 22, 2020
Received:: Feb 29, 2020
Accepted:: Mar 30, 2020
DOI:: 10.5530/ijper.54.3.135

How to cite

Sreeharsha, N., Hiremath, J. G., Al-Dhubiab, B. E., Meravanige, G., Karnati, R. K., Attimarad, M., Nair, A. B., Venugopal, K. N., Morsy, M. A., Pottathil, S., Khan, S., & Molugulu, N. (2020). Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization. Indian Journal of Pharmaceutical Education and Research, 54(3), 826–834. https://doi.org/10.5530/ijper.54.3.135

Abstract

Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.

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Article metadata

Title	Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization
Authors	Nagaraja Sreeharsha; Jagadeesh G Hiremath; Bandar E Al-Dhubiab; Girish Meravanige; Ranjith Kumar Karnati; Mahesh Attimarad; Anroop B Nair; Katharigatta N Venugopal; Mohamed A Morsy; Shinu Pottathil; Saleemmulla Khan; Nagashekhara Molugulu
Affiliations	Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.; Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.; Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.; School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.; Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.; Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.
Corresponding author	sharsha@kfu.edu.sa
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 54, Issue 3 (2020)