In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors

Prasanth, DSNBK; Panda, Siva Prasad; Rao, Atmakuri Lakshmana; Chakravarti, Guntupalli; Teja, Nayudu; Vani, Veenam Bhavya Naga; Sandhya, Tera

doi:10.5530/ijper.54.3s.154

Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 54 | Issue 3s | 2020 | pp. s552–s561Open access

In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors

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¹ Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
² Pharmacology Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
³ Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.
⁴ Department of Pharmaceutics, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.
⁵ Department of Pharmacology, Institute of Pharmaceutical technology, Sri Padmavati Manila Visvavidyalayam, Tirupati, Andhra Pradesh, INDIA.

Correspondence: Email: dsnbkprasanth@kluniversity.in

Published:: Oct 18, 2020
Received:: May 13, 2020
Accepted:: Aug 13, 2020
DOI:: 10.5530/ijper.54.3s.154

How to cite

Prasanth, D., Panda, S. P., Rao, A. L., Chakravarti, G., Teja, N., Vani, V. B. N., & Sandhya, T. (2020). In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors. Indian Journal of Pharmaceutical Education and Research, 54(3s), s552–s561. https://doi.org/10.5530/ijper.54.3s.154

Abstract

Background: Zingiber officinale (Zingiberaceae) has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Methods: Today, research study intended to recognize the Phyto-derived antiviral substances from Zingiber officinale against COVID-19 main protease enzyme and to understand the molecular basis of its activity. Methods: In the present study, 42 molecules obtained from Z. officinale, which are retrieved from the Pubmed database, are studied via docking study. Docking study was performed using Autodock vina and PyRx software. Afterwards, admet SAR, as well as Dru Li to servers, were made use of for drug-likeness prophecy. Results: Our study shows that the nine phytochemicals of Z. officinale are very likely against the main protease enzyme of COVID-19. Utilizing contemporary strategies, these phyto-compounds might use to establish a reliable medication from a natural origin. Conclusion: The substances identified potential as possible anti-virals. However, even more, in-vitro studies are needed to examine their effectiveness versus COVID-19.

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Article metadata

Title	In-silico Strategies of Some Selected Phytoconstituents from Zingiber officinale as SARS CoV-2 Main Protease (COVID-19) Inhibitors
Authors	DSNBK Prasanth; Siva Prasad Panda; Atmakuri Lakshmana Rao; Guntupalli Chakravarti; Nayudu Teja; Veenam Bhavya Naga Vani; Tera Sandhya
Affiliations	Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.; Pharmacology Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.; Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.; Department of Pharmaceutics, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA.; Department of Pharmacology, Institute of Pharmaceutical technology, Sri Padmavati Manila Visvavidyalayam, Tirupati, Andhra Pradesh, INDIA.
Corresponding author	dsnbkprasanth@kluniversity.in
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 54, Issue 3s (2020)