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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 55 | Issue 1 | 2021 | pp. 240–248Open access
Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1
- 1*,
- 2,
- 3,
- 4,
- 1
- 1 Department of Pharmacology, Faculty of Medicine, Minia University, Minia, EGYPT.
- 2 Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, EGYPT.
- 3 Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assuit, EGYPT.
- 4 Department of Medical Biochemistry, Faculty of Medicine, Minia University, Minia University, Minia, EGYPT.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Asmaa Mohamed Abdel-Aziz
Department of Pharmacology, Faculty of Medicine, Minia University, Minia, EGYPT.
Email: asmaaab-delaziz303@yahoo.com
Copyright: © 2021 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 15, 2021
- Received:
- Nov 20, 2019
- Accepted:
- Jan 20, 2021
How to cite
Abdel-Aziz, A. M., Mohammed, H. H., Abdelazem, O., Ahmed, R. F., & Ibrahim, Y. F. (2021). Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1. Indian Journal of Pharmaceutical Education and Research, 55(1), 240–248. https://doi.org/10.5530/ijper.55.1.27
Abstract
Aim/Background: Ovarian I/R is a popular gynecological emergency, complicating ovarian torsion. TTS, reported to have many therapeutic effects along with being an antioxidant, anti- inflammatory and anti-apoptotic agent. The aim of this study was to estimate the probable protective role of Tribulus terrestris Saponin (TTS) in recovering the damaging effects of ischemia-reperfusion (I/R) in the female rats' ovarian tissue. Materials and Methods: TTS was treated to female rats in presence or absence of ovarian I/R. Results: I/R caused ovarian damage, represented by deformity in normal ovarian histological structure, with a significant oxidative and nitrosative stress along with obvious inflammatory damage. Pretreatment with TTS significantly reversed the I/R induced ovarian toxic effects. TTS may have valuable ovarian protective effects against ovarian I/R injury. Conclusion: TTS protection is given via antioxidant, anti-nitrosative, anti-inflammatory and anti-apoptotic mechanisms with advancement of vascular angiogenesis and pituitary-gonadal axis up regulation.
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Article metadata
| Title | Tribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1 |
|---|---|
| Authors | Asmaa Mohamed Abdel-Aziz; Hanaa Hassanein Mohammed; Osama Abdelazem; Rasha Fouad Ahmed; Yasmine F. Ibrahim |
| Affiliations | Department of Pharmacology, Faculty of Medicine, Minia University, Minia, EGYPT.; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, EGYPT.; Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assuit, EGYPT.; Department of Medical Biochemistry, Faculty of Medicine, Minia University, Minia University, Minia, EGYPT. |
| Corresponding author | asmaaab-delaziz303@yahoo.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 55, Issue 1 (2021) |
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