Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 56 | Issue 3 | 2022 | pp. 822–829Open access
Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model
- 1,
- 1,
- 2,
- 3,
- 4,
- 1*
- 1 Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
- 2 Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Alquwayiyah, Shaqra University, Riyadh, SAUDI ARABIA.
- 3 Immunology Unit, Pathology Department, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
- 4 Department of Medical Biochemistry, College of Medicine and Health Sciences, Hadhramout University, Mukalla, YEMEN.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Khalid M Sumaily
Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
Email: ksumaily@ksu.edu.sa
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 7, 2022
- Received:
- Apr 17, 2022
- Accepted:
- Jun 4, 2022
How to cite
Sabi, E. M., Mujamammi, A. H., Althafar, Z. M., Al-Shouli, S. T., Dahman, L. S. B., & Sumaily, K. M. (2022). Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model. Indian Journal of Pharmaceutical Education and Research, 56(3), 822–829. https://doi.org/10.5530/ijper.56.3.134
Abstract
Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy are associated with DM. Objectives: To explore a safer treatment option with no/less adverse effects, we evaluated the potential of Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods: Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After induction, Ficus benghalensis hydroethanolic bark extract was administered to zebrafish in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were analyzed. Results: Treating the streptozotocin-induced group with Ficus benghalensis hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides, and liver enzymes. The histopathological evaluation also showed improvement in the damaged pancreatic tissues. Conclusion: Our results suggest that Ficus benghalensis hydroethanolic bark extract can be used as a potent therapeutic candidate for treating diabetes.
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Article metadata
| Title | Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model |
|---|---|
| Authors | Essa M Sabi; Ahmed H Mujamammi; Ziyad M Althafar; Samia T Al-Shouli; Lotfi S Bin Dahman; Khalid M Sumaily |
| Affiliations | Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.; Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Alquwayiyah, Shaqra University, Riyadh, SAUDI ARABIA.; Immunology Unit, Pathology Department, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.; Department of Medical Biochemistry, College of Medicine and Health Sciences, Hadhramout University, Mukalla, YEMEN. |
| Corresponding author | ksumaily@ksu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 56, Issue 3 (2022) |
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