Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs

Shilpi, Satish; Gurnany, Ekta; Bhatt, Shvetank; Gupta, Pawan K; Sethiya, Neeraj K; Jain, Vikas; Jain, Rupshee

doi:10.5530/ijper.57.3.77

Review ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 3 | 2023 | pp. 625–639Open access

Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs

¹,
²,
³,
⁴,
¹,
⁵,
⁶^*

¹ Department of Pharmaceutics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, INDIA.
² Department of Pharmaceutics, B. Pharmacy College, Rampura, Godhra, Gujarat, INDIA.
³ Department of Pharmacology, School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.
⁴ Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, INDIA.
⁵ Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Karnataka, INDIA.
⁶ Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.

Correspondence: Rupshee Jain
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.
Email: rupsheejain@jssuni.edu.in

Published:: Jun 14, 2023
Received:: Dec 8, 2022
Accepted:: Apr 13, 2023
DOI:: 10.5530/ijper.57.3.77

How to cite

Shilpi, S., Gurnany, E., Bhatt, S., Gupta, P. K., Sethiya, N. K., Jain, V., & Jain, R. (2023). Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs. Indian Journal of Pharmaceutical Education and Research, 57(3), 625–639. https://doi.org/10.5530/ijper.57.3.77

Abstract

Nanosuspension formulation and production techniques are currently undergoing remarkable growth in pharmaceutical industries to address poor aqueous solubility and low bioavailability of active pharmaceutical ingredients. It has some distinct character and benefits over other methodologies used to enhance aqueous solubility. The controlled process including formulation and processing variables provide the requisite shape and size of the drug particles in the form of nanosuspension. Generally, drug particles in the form of nanosuspension can be obtained in the size range of 200 to 1000 nm by manipulating various parameters. The pharmacokinetic parameters of the drugs can also be altered by changing the size of drug particles by developing them in the form of nanosuspension. The current review aims to address the physico-chemical characteristics of nanosuspensions, including various formulation considerations. This review also includes potential applications and recent advancements in the field of nanosizing technology.

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Article metadata

Title	Nanosizing Approaches: Current Trends in the Solubility Enhancement of Poorly Water-soluble Drugs
Authors	Satish Shilpi; Ekta Gurnany; Shvetank Bhatt; Pawan K Gupta; Neeraj K Sethiya; Vikas Jain; Rupshee Jain
Affiliations	Department of Pharmaceutics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, INDIA.; Department of Pharmaceutics, B. Pharmacy College, Rampura, Godhra, Gujarat, INDIA.; Department of Pharmacology, School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.; Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, INDIA.; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Karnataka, INDIA.; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.
Corresponding author	rupsheejain@jssuni.edu.in
Journal	Indian Journal of Pharmaceutical Education and Research
Volume / Issue	Vol. 57, Issue 3 (2023)