Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 57 | Issue 4 | 2023 | pp. 1226–1231Open access
Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis
- 1,
- 1*,
- 1,
- 2,
- 1,
- 1,
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- 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.
- 2 Department of Pharmaceutics, Jinnah University for Women, Karachi, PAKISTAN.
- 3 Department of Chemistry, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PAKISTAN.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Fatima Qamar
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.
Email: fatimamudassar2009@hotmail.com
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Sep 20, 2023
- Received:
- Jan 25, 2023
- Accepted:
- Aug 14, 2023
How to cite
Bashir, S., Qamar, F., Naveed, S., Zainab, S., Sadia, H., Sana, A., & Muzafar, W. (2023). Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis. Indian Journal of Pharmaceutical Education and Research, 57(4), 1226–1231. https://doi.org/10.5530/ijper.57.4.146
Abstract
Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation. Materials and Methods: Mediterranean C18 column with dimensions of 150mm×4.6mm was used with HPLC Shimadzu LC-20 AT model, Version 1:62 is used for processing of chromatograms at room temperature (25± 2°C). 1 mL per minute was the flow rate and detector were set at 254nm with mobile Phase consisting of 85:10:5 v/v methanol: water: acetonitrile. Results: The developed method proved to be accurate, simple, effective precise and reproducible. One way ANOVA was also applied for further confirmation of the results. Conclusion: The method is applicable for the routine analysis of drugs in API and in formulation and for studying in vitro interaction studies.
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Article metadata
| Title | Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis |
|---|---|
| Authors | Sania Bashir; Fatima Qamar; Safila Naveed; Syeda Zainab; Halima Sadia; Aisha Sana; Wajeeha Muzafar |
| Affiliations | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.; Department of Pharmaceutics, Jinnah University for Women, Karachi, PAKISTAN.; Department of Chemistry, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PAKISTAN. |
| Corresponding author | fatimamudassar2009@hotmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 57, Issue 4 (2023) |
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