Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 60 | Issue 3 | 2026 | pp. 1189–1198Open access
Phytochemical Profiling and Evaluation of Cytotoxic Potential of Cucumis prophetarum L. Fruit Extract
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- 1 Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.
- 2 Health Research Centre, Jazan University, Jazan, SAUDI ARABIA.
- 3 Environment and Nature Research Centre, Jazan University, Jazan, SAUDI ARABIA.
- 4 Center for Global Health Research, Saveetha Medical College, and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Kuthambakkam, Tamil Nadu, INDIA.
- 5 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, SAUDI ARABIA.
- 6 Department of Clinical Pharmacy, Pharmacy Practice Research Unit, Faculty of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Sadique Akhtar Javed
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.
Email: sajaved@jazanu.edu.sa
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 23, 2026
- Received:
- Jan 12, 2026
- Accepted:
- Apr 8, 2026
How to cite
Javed, S. A., Khalid, A., Hassani, R., Mohan, S., Abdalla, A. N., Rehman, Z. U., Najmi, A., Zoghebi, K., Makeen, H. A., & Albratty, M. (2026). Phytochemical Profiling and Evaluation of Cytotoxic Potential of Cucumis prophetarum L. Fruit Extract. Indian Journal of Pharmaceutical Education and Research, 60(3), 1189–1198. https://doi.org/10.5530/ijper.20262051
Abstract
Objectives: The present study examined phytochemical composition of ethanolic extract and evaluated cytotoxic properties of Cucumis prophetarum L. Materials and Methods: Phytochemical composition of extract was evaluated by GC-MS and screened for cytotoxic activity by MTT assay. The human cancer cell-lines including MCF7, A2780, HT29, and Normal Fetal Lung Fibroblasts (MRC5), used to determine cytotoxicity and selectivity index of the extract. Results and Discussion: Fatty acid esters (43.74%), phthalic acid diesters (11.38%), fatty acid silyl esters (4.15%), and siloxane derivatives (3.88%), aromatic monoterpenes (2.75%) and pentacyclic triterpenoids (1.21%) were the main constituents detected in the extract. Results indicated that MCF7 cells exhibited highest sensitivity (IC50: 3.30 μg/mL) and the extract was selective and caused early apoptosis against the same cell-lines. Conclusion: The outcomes of this investigation indicated that the bioactive components in the extract might be employed for cytotoxic purposes. The study will be useful to establish the scientific basis for ethnopharmacological usage of the tested plant.
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Article metadata
| Title | Phytochemical Profiling and Evaluation of Cytotoxic Potential of Cucumis prophetarum L. Fruit Extract |
|---|---|
| Authors | Sadique Akhtar Javed; Asaad Khalid; Rym Hassani; Syam Mohan; Ashraf Nabiel Abdalla; Zia ur Rehman; Asim Najmi; Khalid Zoghebi; Hafiz Antar Makeen; Mohammed Albratty |
| Affiliations | Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.; Health Research Centre, Jazan University, Jazan, SAUDI ARABIA.; Environment and Nature Research Centre, Jazan University, Jazan, SAUDI ARABIA.; Center for Global Health Research, Saveetha Medical College, and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Kuthambakkam, Tamil Nadu, INDIA.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah, SAUDI ARABIA.; Department of Clinical Pharmacy, Pharmacy Practice Research Unit, Faculty of Pharmacy, Jazan University, Jazan, SAUDI ARABIA. |
| Corresponding author | sajaved@jazanu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 60, Issue 3 (2026) |
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