Open access · Peer reviewed · No APCs
Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 60 | Issue 3s | 2026 | pp. s944–s953Open access
Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement
- 1*,
- 2,
- 3
- 1 Department of Pharmaceutical Science, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.
- 2 Department of Pharmacology, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.
- 3 Department of Pharmaceutics, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Kajal Sunil Shinde
Department of Pharmaceutical Science, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.
Email: kajalshinde893@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 2, 2026
- Received:
- Dec 18, 2026
- Accepted:
- Apr 8, 2026
How to cite
Shinde, K. S., Jangme, C. M., & Patil, A. R. (2026). Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement. Indian Journal of Pharmaceutical Education and Research, 60(3s), s944–s953. https://doi.org/10.5530/ijper.20262145
Abstract
Aim/Background: Naftifine hydrochloride, a BCS Class IV antifungal agent, suffers from poor aqueous solubility, limiting its therapeutic efficacy. This study aims to enhance its solubility using a nanoemulsion-based drug delivery system. Materials and Methods: A systematic formulation approach identified oleic acid, Kolliphor® RH40, and Transcutol-P® as optimal components. Pseudo ternary phase diagrams have been utilized to identify and select the optimal emulsification zone and a 3² factorial design optimized the formulation. Results: The nanoemulsion demonstrated improved solubility, thermodynamic stability, and uniform globule size. Conclusion: These results indicate that nanoemulsion technology holds great potential for improving both the solubility and bioavailability of Naftifine hydrochloride for effective topical antifungal therapy.
Keywords
Subject
Article metadata
| Title | Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement |
|---|---|
| Authors | Kajal Sunil Shinde; Chandrapraphu Motichand Jangme; Abhinandan Raosaheb Patil |
| Affiliations | Department of Pharmaceutical Science, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.; Department of Pharmacology, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.; Department of Pharmaceutics, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA. |
| Corresponding author | kajalshinde893@gmail.com |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 60, Issue 3s (2026) |
Also in this issue
- Role of Staple Food Fortification in Combating Micronutrient Deficiencypp. s864–s873
- Advances in Green Bromination: Emerging Eco-Friendly Reagents and Methodologiespp. s874–s881
- Insight into the Recent Advancement of 1,3,4 Oxadiazoles as Potential EGFR and Telomerase Inhibitory for Anticancer Activitypp. s882–s895
- Gold Nanoparticles: Innovative Supramolecular Platforms for Targeted Drug Delivery and Bioorthogonal Catalysispp. s896–s905
- Recent Advances in Phytoconstituent-Based Alpha Glucosidase Inhibitors and Therapeutic Potential for Type 2 Diabetes Mellituspp. s906–s917
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026