Open access · Peer reviewed · No APCs
Original Research ArticleInternational Journal of Pharmaceutical InvestigationVol. 1 | Issue 2 | 2011 | pp. 93–98Open access
Effect of agar—gelatin compositions on the release of salbutamol tablets
- 1,
- 2,
- 1,
- 2,
- 1*
- 1 School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory.
- 2 Jawaharlal Nehru University, 1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Himadri B Bohidar
School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory.
Email: bohi0700@mail.jnu.ac.in
Copyright: © 2011 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 28, 2011
- Received:
- Dec 6, 2010
- Accepted:
- Jan 6, 2011
How to cite
Saxena, A., Tahir, A., Kaloti, M., Ali, J., & Bohidar, H. B. (2011). Effect of agar—gelatin compositions on the release of salbutamol tablets. International Journal of Pharmaceutical Investigation, 1(2), 93–98. https://doi.org/10.4103/2230-973X.82407
Abstract
The study was designed for the development of salbutamol-modified release tablet using various polymer composition of agar, gelatin A and gelatin B. The purpose is to observe the role of polymer composition on the modified dissolution rate of salbutamol. Pre-formulation trials were initiated by comprising different ratios of polymer blend in the tablets. Formulations were optimized based on their invitro release performed in enzyme free simulated gastric fluid (0.1 N HCl, pH 1.2). Dissolution profiles of tablets were compared among the tablets made of agar, gelatin A, gelatin B and their blends agar-gelatin A, agar-gelatin B, gelatin A-gelatin B and agar-gelatin A-gelatin B in 1:1 ratio. Polymer compositions were fixed based on our desired sustaining activity of the tablet which showed a biphasic release profile with immediate release followed by sustained release. Polymer blends were more effective in controlling drug release. The better controlling behavior of polymer blends was explained by specific interaction between polymer components, their network structure and polymer–drug interaction.
Keywords
Subject
Article metadata
| Title | Effect of agar—gelatin compositions on the release of salbutamol tablets |
|---|---|
| Authors | Anita Saxena; Abu Tahir; Mandeep Kaloti; Javed Ali; Himadri B Bohidar |
| Affiliations | School of Physical Sciences, Nanomaterials and Nanocomposites Laboratory.; Jawaharlal Nehru University, 1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, INDIA. |
| Corresponding author | bohi0700@mail.jnu.ac.in |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 1, Issue 2 (2011) |
Also in this issue
- Nanopharmaceuticspp. 61
- Mucoadhesion; A prerequisite or a constraint in nasal drug delivery?pp. 62–63
- Recent trends in vaccine delivery systems: A reviewpp. 64–74
- Developing micro-/nanoparticulate drug delivery systems using “design of experiments”pp. 75–87
- Preparation of poly(NIPAAm)-Pluronic F68 as a thermosensitive surfactant for a controlled drug releasepp. 88–92
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026