Design and Development of Chitosan Beta-cyclodextrin based Nasal Mucoadhesive Microspheres of Clarithromycin

Objectives: The present systematic research is to design, develop clarithromycin nasal mucoadhesive microspheres for the utilisation in respiratory tract infection as alternative route of drug delivery. Methods: Current study designed to formulate, evaluated by using chitosan, beta cyclodextrin with modified emulsion lyophilisation method. 24 factorial design was used in optimization technique. Characterisation of prepared microspheres will be subjected for particle size and size distribution, drug entrapment study, in vitro drug diffusion studies and ex vivo mucoadhesion, surface morphology, zeta potential, infra-red radiation, differential scanning calorimetry, X-ray diffraction and stability studies. Results: The optimised formulation of predicted values of chitosan 0.604, Beta cylclodextrin 0.7633, Propeller Mixing Speed 9369 and Lyocycle temperatue of -42.8°C, Particle Size 14.06 µm, Entrapment efficiency 73.32%, Mucoadhesion 81.03 % and Maximum drug release 80.56%. Other finding results were satisfactory in control of quality attributes. Conclusion: Developed microspheres can be potential highlight on utilisation of clarithromycin as nasal drug delivery with beneficial as alternative dosage form for respiratory tract infections.