Open access · Peer reviewed · No APCs
Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 12 | Issue 4 | 0202 | pp. 479–482Open access
Caloric Vestibular Stimulation Alleviates the Motor Dysfunctions in a Mouse Model of Parkinson’s Disease
- 1,2,3,
- 2*,
- 4,
- 5,
- 6
- 1 Department of Physiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, MALAYSIA.
- 2 Department of Physiology, Saveetha Medical College, Saveetha Institute of Technical and Medical Sciences (SIMATS), Chennai, Tamil Nadu, INDIA.
- 3 Unit of Physiology, Faculty of Medicine, AIMST University, Kedah, MALAYSIA.
- 4 Department of Pharmacology, Faculty of Pharmacy, AIMST University, Kedah, MALAYSIA.
- 5 Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Malappuram, Kerala, INDIA.
- 6 Department of Biochemistry, Faculty of Medicine, Bioscience, and Nursing, MAHSA University, Selangor, MALAYSIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Archana Rajagopalan
Department of Physiology, Saveetha Medical College, Saveetha Institute of Technical and Medical Sciences (SIMATS), Chennai, Tamil Nadu, INDIA.
Email: professorarchana2017@gmail.com
Copyright: © 0202 Manuscript Technomedia. This is an open access article.
- Published:
- Oct 6, 202
- Received:
- Jul 24, 2022
- Accepted:
- Sep 1, 2022
How to cite
Narayanam, H., Rajagopalan, A., Parasuraman, S., Christapher, P. V., & Chinni, S. V. (0202). Caloric Vestibular Stimulation Alleviates the Motor Dysfunctions in a Mouse Model of Parkinson’s Disease. International Journal of Pharmaceutical Investigation, 12(4), 479–482. https://doi.org/10.5530/ijpi.2022.4.82
Abstract
Background: Parkinson’s disease (PD) is one of the most common degenerative disorders of the ageing brain. Currently, there is no cure for PD and most of the available treatments only aim to reverse the dopamine deficiency and relieve its symptoms. Caloric vestibular stimulation (CVS) is believed to help in relieving motor symptoms of PD. Hence, the present study is planned to evaluate the effect of CVS on behavioral changes in PD Mice. Materials and Methods: Twenty-four healthy male Swiss albino mice divided into four groups (n=6) were used for the study. PD was induced by giving an intraperitoneal injection of MPTP for 5 consecutive days. Bilateral CVS was given with hot water (temperature 40°C) for 15 days. Changes in behaviour (locomotor activity, grip strength, motor coordination, immobilization time) were measured on day 1 and day 15 and the results were statistically analysed. Results: The PD group showed a significant decrease in locomotor activity, muscular strength (fall on time), grip strength and immobilization time when compared to the control group, whereas CVS prevented the symptoms of PD when compared with the PD group. Conclusion: Caloric vestibular stimulation was effective in alleviating behavioral alterations in Parkinson-induced mice.
Keywords
Subject
Article metadata
| Title | Caloric Vestibular Stimulation Alleviates the Motor Dysfunctions in a Mouse Model of Parkinson’s Disease |
|---|---|
| Authors | Harini Narayanam; Archana Rajagopalan; Subramani Parasuraman; Parayil Varghese Christapher; Suresh V Chinni |
| Affiliations | Department of Physiology, Faculty of Medicine, Manipal University College Malaysia, Melaka, MALAYSIA.; Department of Physiology, Saveetha Medical College, Saveetha Institute of Technical and Medical Sciences (SIMATS), Chennai, Tamil Nadu, INDIA.; Unit of Physiology, Faculty of Medicine, AIMST University, Kedah, MALAYSIA.; Department of Pharmacology, Faculty of Pharmacy, AIMST University, Kedah, MALAYSIA.; Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Malappuram, Kerala, INDIA.; Department of Biochemistry, Faculty of Medicine, Bioscience, and Nursing, MAHSA University, Selangor, MALAYSIA. |
| Corresponding author | professorarchana2017@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 12, Issue 4 (0202) |
Also in this issue
- Responsible Research in Planning for Animal Experiments – A Mini Reviewpp. 400–402
- A Guidance on Premarket Pathways for Combination Product in the United States of Americapp. 403–407
- Nutritional Values and Therapeutic Uses of Capra hircus Milkpp. 408–417
- In silico Toxicity Prediction on Novel Antiobesity Drug Using Cheminformatics Approachespp. 418–422
- In vitro Evaluation of Antioxidant Property, Chemo-profiling, Elemental Analysis of Morinda umbellata L.pp. 423–429
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026