Open access · Peer reviewed · No APCs
Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 13 | Issue 2 | 2023 | pp. 243–247Open access
Co-crystals: A Novel Approach to Improve the Solubility of Apixaban
- 1*,
- 2,
- 3,
- 4,
- 5,
- 5,
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- 1 Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, INDIA.
- 2 Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, INDIA.
- 3 Department of Pharmaceutics, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.
- 4 Department of Pharmaceutics, MCE Society’s Allana College of Pharmacy, Pune, Maharashtra, INDIA.
- 5 Department of Pharmaceutics, Rajmata Jijau Shikshan Prasarak Mandal’s, Institute of Pharmacy, Pune, Maharashtra, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Amit V Asati
Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, INDIA.
Email: avasati28@rediffmail.com
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 3, 2023
- Received:
- Nov 16, 2022
- Accepted:
- Jan 4, 2023
How to cite
Asati, A. V., Salunkhe, K. S., Rajput, R. P. S., Chintamani, S. R., Khairnar, A. U., Patil, N. S., & Chintamani, R. N. (2023). Co-crystals: A Novel Approach to Improve the Solubility of Apixaban. International Journal of Pharmaceutical Investigation, 13(2), 243–247. https://doi.org/10.5530/ijpi.13.2.033
Abstract
Objectives: The current study work was aimed to improve the solubility of Apixaban by forming co-crystals. Materials and Methods: Two solvents mainly Dimethyl Sulphoxide (DMSO) and 2,2,2-trifluoroethanol were tried during the formulation of co-crystals. The other chemicals oxalic acid, adipic acid and L-Tartaric acid were used. Results: From the different trials it was concluded that oxalic acid and DMSO combination with the drug gave the better results for improvement in the solubility. Hence the batch F3 was analysed further. The melting point of F3 was found lower than pure drug. Drug content was found optimum as 95.06 ±0.65%. FTIR-spectra demonstrated the combined peaks of drug and oxalic acid. DSC thermogram showed the sharp endothermic peak similar to pure drug. SEM and XRD spectra confirmed the formation of co-crystals. Conclusion: It was found that formation of co-crystals of apixaban and oxalic acid was satisfactory and it was beneficial to improve the solubility of the apixaban
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Article metadata
| Title | Co-crystals: A Novel Approach to Improve the Solubility of Apixaban |
|---|---|
| Authors | Amit V Asati; Kishor S Salunkhe; Rudra Pratap Singh Rajput; Sonali R Chintamani; Akshay U Khairnar; Nilesh S Patil; Ravindra N Chintamani |
| Affiliations | Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Ahmednagar, Maharashtra, INDIA.; Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, INDIA.; Department of Pharmaceutics, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, INDIA.; Department of Pharmaceutics, MCE Society’s Allana College of Pharmacy, Pune, Maharashtra, INDIA.; Department of Pharmaceutics, Rajmata Jijau Shikshan Prasarak Mandal’s, Institute of Pharmacy, Pune, Maharashtra, INDIA. |
| Corresponding author | avasati28@rediffmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 13, Issue 2 (2023) |
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