Exploring the Anti-bacterial Potential of Novel 2-Aminophenyl-2-(2,4,5-Triphenylimidazole) Acetate Derivatives: A Comprehensive Design and Synthesis Approach

Background: Antibiotic resistance is a growing concern, and the development of new anti-bacterial agents is crucial. 2-aminophenyl-2-(2,4,5-triphenylimidazole) derivatives have shown potential as anti-bacterial agents in previous studies, and this study aims to further explore their potential. Materials and Methods: Several 2-aminophenyl-2-(2,4,5-triphenylimidazole) derivatives have been developed and synthesized in this work. Using the disc diffusion technique, their anti-bacterial activity was assessed against Escherichia coli and Staphylococcus aureus. Additionally, the compounds' drug likeness and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics were assessed. To learn more about how chemical compounds attach to the biotin protein ligase, molecular docking investigations were carried out. Results: The synthesized compounds exhibited varying degrees of anti-bacterial activity, with AC6 showing the highest activity against both E. coli and S. aureus. The compounds were found to adhere to Lipinski's rule of five, indicating good drug likeness, and exhibited favourable ADMET properties. The molecular docking studies revealed that the compounds had favourable binding modes with biotin protein ligase (PDB ID: 4DQ2). Conclusion: The 2-aminophenyl-2- (2,4,5-triphenylimidazole) derivatives designed and synthesized in this study exhibited promising anti-bacterial activity against E. coli and S. aureus. The compounds also demonstrated good Drug likeness and favourable ADMET properties. The molecular docking studies provided insights into the binding modes of the compounds with biotin protein ligase. These results suggest that 2-aminophenyl-2-(2,4,5-triphenylimidazole) derivatives have potential as anti-bacterial agents and warrant further investigation.