Synthesis, Characterization and Attenuation of Strychnine-Induced Epilepsy on 3-(3-Aminophenyl)- 1-[3-(2-Hydroxyphenyl)-3-Oxopropanoyl]-5,5-Diphenylimidazolidine-2,4-Dione Derivatives on Experimental Rats

Background

It was a heterocyclic hydrocarbon whose molecular structure has some fundamental structural features. In this study, we synthesise eleven different imidazolidine-2,4-dione derivatives that have convulsive properties. Seizures can be divided into two categories: partial and generalised. While partial seizures occur when electrical activity spikes in only one area of the brain, generalised seizures involve aberrant electrical activity on both sides of the patient’s brain.

Materials and Methods

2-chloromethyl benzene; 1-phenyl methanone; 4-oxo-4-phenoxybutanoic acid; 1-phenyl ethanone; phenol acetate; 4-aminophenol; oxalic acid etc., were used for the synthesis. Every chemical was of the analytical variety. Add 1 g of phenytoin to the flask with a round bottom. To the 100 mL RBF, add 1 mL of glacial acetic acid and 3 amino phenols. Refluxing the reaction mixture, heat it for 2 hr at a temperature between 80 and 100°C. Add 10 mL of crushed ice to the reaction mixture to cool it down. Pour in more ice-cold water. Gather the product after filtering the reaction mixture.

Results

overall compounds had strong anti-convulsive properties against epilepsy. (BJ)-(scheme 1B); (BG)-(Scheme 1B): (BE)-(scheme 1B); (BN)-(scheme 1B); (BM)- (scheme 1B) had strong anti-convulsive properties against epilepsy.

Conclusion

Research examining the relationship between structural activity and activity has shown that compounds containing imidazolidine derivatives with an electron-withdrawing group exhibited higher levels of activity compared to those with an electron-donating group.