Open access · Peer reviewed · No APCs
Original ArticleInternational Journal of Pharmaceutical InvestigationVol. 15 | Issue 2 | 2025 | pp. 508–515Open access
Evaluation of in vitro Anti-Inflammatory Activity of Zolpidem
- 1,
- 1*,
- 1
- 1 Department of Pharmacology, Sri Ramachandra Medical College and RI, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: K Karthika
Department of Pharmacology, Sri Ramachandra Medical College and RI, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, INDIA.
Email: drkkarthika@gmail.com
Copyright: © 2025 Manuscript Technomedia. This is an open access article.
- Published:
- Feb 12, 2025
- Received:
- Sep 12, 2024
- Accepted:
- Dec 29, 2024
How to cite
Lalit, R. S., Karthika, K., & Ramasamy, K. (2025). Evaluation of in vitro Anti-Inflammatory Activity of Zolpidem. International Journal of Pharmaceutical Investigation, 15(2), 508–515. https://doi.org/10.5530/ijpi.20250103
Abstract
Objectives
Zolpidem, a novel non-benzodiazepine sedative, has shown antioxidant, muscle relaxant, anti-convulsant and anti-anxiety properties. The Objective of our study is to evaluate it’s in vitro anti-inflammatory activity.
Materials and Methods
Three assays were done: Protein Denaturation, Erythrocyte Membrane Stabilization and Proteinase Inhibition Assays using standard techniques.
Results
Zolpidem showed maximal inhibition of 88.34 ± 0.09%, 82.41 ± 0.41% and 79.20 ± 0.41% in the Protein Denaturation, Erythrocyte Membrane Stabilization and Proteinase Inhibition Assays.
Conclusion
This shows that Zolpidem possesses excellent anti-inflammatory activity and untapped potential to be used in neurodegenerative diseases. Further in vivo studies could be done to further explore this activity.
Keywords
Subject
Article metadata
| Title | Evaluation of in vitro Anti-Inflammatory Activity of Zolpidem |
|---|---|
| Authors | Rhea Surana Lalit; K Karthika; Kavitha Ramasamy |
| Affiliations | Department of Pharmacology, Sri Ramachandra Medical College and RI, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, INDIA. |
| Corresponding author | drkkarthika@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 15, Issue 2 (2025) |
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