Review ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 2 | 2026 | pp. 405–413Open access
The Multifaceted Potential of Tirzepatide in Metabolic and Non-Metabolic Disorders
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- 1 Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Vijayakumar Thangavel Mahalingam
Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, INDIA.
Email: vijayakm2@srmist.edu.in
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Feb 2, 2026
- Received:
- Aug 14, 2025
- Accepted:
- Dec 24, 2025
How to cite
Mohamed, T., Mahadevan, S., Prabhakaran, J. V., Venkatesan, S., Fayaz, M., & Mahalingam, V. T. (2026). The Multifaceted Potential of Tirzepatide in Metabolic and Non-Metabolic Disorders. International Journal of Pharmaceutical Investigation, 16(2), 405–413. https://doi.org/10.5530/ijpi.20260349
Abstract
Tirzepatide is redefining the treatment landscape for metabolic and non-metabolic disorders. By uniquely harnessing two critical hormonal pathways, the review provides comprehensive insights into how Tirzepatide’s dual mechanism of action sets it apart from existing therapies. Noteworthy findings from clinical and preclinical studies underscore Tirzepatide's potential in addressing complex conditions Highlighting its role in cardio protection, renal protection, neuroprotection, bone health in osteoporosis, reproductive health, respiratory health, genetic conditions management, cancer-associated weight gain, psychiatric illness and antipsychotic drug-induced obesity, inflammatory conditions, and other conditions. This comprehensive review not only underscores tirzepatide’s potential to address unmet clinical needs but also identifies key avenues for future research, aiming to elucidate its broader applicability and optimize patient outcomes. By highlighting these novel insights, this review positions tirzepatide as a transformative agent with the potential to redefine therapeutic paradigms across diverse medical domains.
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Article metadata
| Title | The Multifaceted Potential of Tirzepatide in Metabolic and Non-Metabolic Disorders |
|---|---|
| Authors | Thalal Mohamed; Srimathi Mahadevan; Jayashri Vidya Prabhakaran; Sundari Venkatesan; Mohammed Fayaz; Vijayakumar Thangavel Mahalingam |
| Affiliations | Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, INDIA. |
| Corresponding author | vijayakm2@srmist.edu.in |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 2 (2026) |
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