Review ArticleInternational Journal of Pharmaceutical InvestigationVol. 16 | Issue 4 | 2026 | pp. 1251–1261Open access
Smart Implants: Transforming Drug Delivery Systems
- 1*,
- 1
- 1 Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha, Maharashtra, INDIA.
Published in International Journal of Pharmaceutical Investigation
Correspondence: Sakshi Wankhede
Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha, Maharashtra, INDIA.
Email: wankhedes2001@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2026
- Received:
- Jan 28, 2025
- Accepted:
- May 10, 2026
How to cite
Wankhede, S., & Pethe, A. (2026). Smart Implants: Transforming Drug Delivery Systems. International Journal of Pharmaceutical Investigation, 16(4), 1251–1261. https://doi.org/10.5530/ijpi.20260195
Abstract
Smart implants represent an advanced class of biomedical devices integrating sensing systems, microelectronics and targeted drug release mechanisms. These technologies enable adaptive, real time drug delivery based on physiological inputs, thereby improving therapeutic outcomes, minimizing side effects, and enhancing patient compliance. A comparative evaluation of current smart implants systems was carried out with respect to their drug delivery efficiency, biosensing capabilities and personalized medicine applications. Innovations in material science, miniaturization and energy harvesting techniques were reviewed to determine their role in overcoming technical limitations. The role of wireless connectivity, wearable integration and AI assisted analytics was assessed to understand their contribution to real time monitoring and controlled drug release. Smart implants demonstrated high therapeutic potential, particularly for chronic diseases such as cancer, diabetes, cardiovascular disorders and chronic pain. Integrated biosensors and microelectronic systems enabled continuous monitoring and adaptive drug delivery, resulting in greater precision and reduced need for manual intervention. The use of biocompatible materials and self-powered systems further enhanced device performance and longevity. AI-enabled predictive algorithms and wireless communication significantly improved real-time decision-making and healthcare connectivity. These advancements collectively suggest reduced hospitalization, improved access to continuous therapy, and enhanced patient specific treatment plans. Smart implants offer a transformative approach to modern healthcare through real-time, personalized, and minimally invasive drug delivery systems. With continuous progress in nanotechnology, biosensor design, and AI assisted treatment prediction, smart implants are expected to remain at the forefront of advanced medical therapies for decades. They hold strong potential for reducing treatment burden, improving accessibility, and providing highly individualized care.
Keywords
Subject
Article metadata
| Title | Smart Implants: Transforming Drug Delivery Systems |
|---|---|
| Authors | Sakshi Wankhede; Anil Pethe |
| Affiliations | Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (DU), Sawangi (Meghe), Wardha, Maharashtra, INDIA. |
| Corresponding author | wankhedes2001@gmail.com |
| Journal | International Journal of Pharmaceutical Investigation |
| Volume / Issue | Vol. 16, Issue 4 (2026) |
Also in this issue
- AI-Based Approaches for Early Detection and Prevention of Diabetespp. 1202–1209
- Bridging the Digital Gap: A Comparative Analysis of Electronic Regulatory Submission Systems in India and Established Marketspp. 1210–1215
- Biosensor-Based Innovations in Therapeutic Drug Monitoring: Bridging Traditional Methods and Precision Medicinepp. 1216–1230
- Toward Application of Microsponges for Topical Drug Delivery: A Reviewpp. 1231–1243
- Pharmaceutical Microbiology: Navigating Future Challenges and Innovationspp. 1244–1250
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026