Antidiabetic Potential of Flavones on Streptozotocin-induced Diabetes Mellitus in Rat

Objectives: The objective of the study was to develop new antidiabetic agents from synthetic route. Methods: An attempt was made to synthe- size various flavones. The structures of the compounds were elucidated by UV, IR, 1H-NMR and mass spectrometry. Furthermore, an in vivo antidiabetic activity study was carried out by streptozotocin induced model. Biochemical parameters were extensively studied to support anti-diabetic potential of synthesized flavones. Results: The study reveals that flavones such as F1, F2, F3, F5 and F8 were potentially considered for in-vivo anti- diabetic activity. Fasting blood glucose and biochemical parameters like to- tal protein, urea and creatinine, SGOT, SALP and SGPT were performed for the biological evaluation and compared with that of standard glibenclamide (5 mg/kg). Among the five consolidated flavones, F8 possess high signifi- cant (p < 0.01) results and restores the blood glucose level, liver enzymes and renal parameters. Based on these results, a promising potent drug would be developed in the management of diabetes mellitus. Conclusion: In-vivo evaluations of selected compounds were carried out for its anti- diabetic activity considering different biochemical parameters. Some of the selected flavones showed excellent and noticeable antidiabetic activity.