Bibliometric Analysis of Literature on Acute Respiratory Distress Syndrome Treatments Published Between 2000 and 2019

Acute Respiratory Distress Syndrome (ARDS) is a common and extensively researched condition, and treatment modalities are continuously being developed and improved. Although the literature on ARDS treatment is vast, only one prior bibliographic analysis of trends in this area has been published. Objective We aimed to systematically evaluate the literature on ARDS treatments published between 2000 and 2019 from the perspective of bibliometrics. Research design and methods: Literature retrieval was performed in PubMed and in Web of Science Core Collection. Studies were analyzed by publication and temporal trends. CiteSpace was used to perform Co-occurrence analysis for institutions and reference co-citation analysis for research topics. Burst keyword detection was used to predict future areas of research interest in the field. Findings: A total of 13,933 articles were retrieved. The journal Critical Care Medicine published the largest number of articles (956, 6.86%). The University of Toronto was affiliated with the most publications (574, 4.28%) and had the highest degree of betweenness centrality, indicating extensive inter-institution collaboration. The papers on ARDS treatment published between 2000 and 2019 were grouped into 10 major clusters, three of which indicated recent activity (“acute lung injury,” “long-term outcome,” and “extracorporeal membrane oxygenation”). Fifteen burst keywords/terms were identified, including extracorporeal membrane oxygenation, meta-analysis, and oxidative stress. Implications: On the basis of the literature published in the preceding 20 years, the study of ARDS treatment is an ongoing concern. Extracorporeal membrane oxygenation was an active focus of research in this field. It and oxidative stress are likely to become major topics of research interest in the near future. Meta-analysis will be a popular method in analyzing the efficacy of ARDS treatments.