Original ArticleJournal of Young PharmacistsVol. 10 | Issue 1 | 2018 | pp. 37–40Open access
Formulation and Characterization of Rice Bran Oil in Alginate Microcapsules
- 1,4,
- 1,
- 2,
- 3*
- 1 Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
- 2 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
- 3 Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
- 4 Departement of Pharmaceutical Science, Faculty of Pharmacy, Universitas Muhammadiyah Banjarmasin, INDONESIA.
Published in Journal of Young Pharmacists
Correspondence: Fadlina Chany Saputri
Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
Email: fadlina.chany@farmasi.ui.ac.id
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 22, 2018
- Received:
- Nov 14, 2017
- Accepted:
- Dec 13, 2017
How to cite
Nashihah, S., Mun’im, A., s, S., & Saputri, F. C. (2018). Formulation and Characterization of Rice Bran Oil in Alginate Microcapsules. Journal of Young Pharmacists, 10(1), 37–40. https://doi.org/10.5530/jyp.2018.10.10
Abstract
Objective: This study was conducted to evaluate the encapsulated Rice Bran Oil with sodium alginate to improve stability and reduce rancidity by using ionic gelation method. Method: Response Surface Methodology design were used to optimized microcapsule condition. Thirteen formula of Rice Bran Oil microcapsules were prepared in differential ratio and evaluated for physical characteristic, level of γ-oryzanol content, entrapment efficiency, in vitro release of Rice Bran Oil microcapsules. Results: Between all formulas, the ratio of 40:50:10 for Rice Bran Oil, sodium alginate and emulgator respectively, had the highest entrapment efficiency and in the physical characteristic parameter. The microcapsules were in particle range of 580 and 747μm. the in vitro evaluation showed that RBO was release from microcapsules in intestinal simulated digestion (50.64%) for 8h. Conclusion: Rice Bran Oil, sodium alginate and emulgator with the ratio of 40:50:10 indicated establish formula to create RBO microcapsules.
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Article metadata
| Title | Formulation and Characterization of Rice Bran Oil in Alginate Microcapsules |
|---|---|
| Authors | Siti Nashihah; Abdul Mun’im; Sutriyo s; Fadlina Chany Saputri |
| Affiliations | Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.; Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.; Departement of Pharmaceutical Science, Faculty of Pharmacy, Universitas Muhammadiyah Banjarmasin, INDONESIA. |
| Corresponding author | fadlina.chany@farmasi.ui.ac.id |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 10, Issue 1 (2018) |
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