Anti-Inflammatory Activity of Combined Aerodisperse System in the Conditions of Experimental Cervical Lymphadenite

Objective: The aim of this study was to assess the presence of an antiinflammatory activity of a new combined aerodisperse system under conditions experimental lymphadenite. Materials and Methods: Lymphadenite was reproduced by injection of bacterial lipopolysaccharide into the lymph node. The test spray and comparison spray (Tantum Verde®) were introduced by the irrigation of the posterior pharyngeal wall for 3 days after the induction of inflammation in doses: 0.5 mg / kg; 1 mg / kg; 1.5 mg / kg, 2 mg / kg. After this time estimate the concentration of CRP, TNF-α, leukocytes in the blood and the severity of the inflammatory edema of the lymph node. Results: test spray (all doses) provide reduce the concentration of CRP, TNF-α and leukocytes in the blood, and in doses of 0.5 mg / kg and 1 mg / kg - inflammatory edema of the lymph nodes by 12.9% (p <0.05) and 9.3% (p<0.05), respectively. In this case, the anti-inflammatory effect of the test spray in doses of 1 mg / kg is comparable to that of benzidamine. Conclusion: The test spray has an anti-inflammatory effect comparable to the pharmacological effect with the benzidamine, and may be included in further development, with the goal of creating a drug for the treatment of URT diseases. Since the increase in the dose of the test spray does not increase the pharmacological activity, the optimal dose of the test spray can be considered 1 mg, which is equivalent to 2 sprayings.