Drug Utilization Evaluation of Anti-diabetics in Type 2 Diabetes Mellitus Patients with or without Comorbidities in a Tertiary Care Teaching Hospital

Background: Evaluation of utilization pattern and prescribing trend of anti-diabetics is of paramount importance to promote rational drug use. Objectives: The primary objective of this research is to assess drug utilization evaluation of anti-diabetics in type 2 diabetes mellitus patients with or without comorbidities. Methods: A prospective observational study was carried out for six months in the inpatient medicine department of Chigateri District, Hospital Davanagere. Results: A total of 151 patients were enrolled, out of which 93 (62%) patients were males and 58 (38%) patients were females. Most of the patients belong to the age group of 51-60 (29%) years, followed by 61-70(28%) years. The pattern of drug prescription in diabetes shows that insulin (52%) was the most utilized monotherapy followed by metformin (47%). Among dual therapy, 34(60%) patients were treated with the combination of metformin+ glimepiride. A total of 8 patients were treated with triple therapy, out of which 4 (50%) patients were prescribed a combination of metformin+glimepride+human actrapid. Conclusion: The prescribing trend was found to be monotherapy with insulin followed by dual therapy and triple therapy. The combination of biguanides and sulfonylureas was the most commonly prescribed antidiabetic regimen among dual therapy.