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PharmacologyJournal of Young PharmacistsVol. 2 | Issue 3 | 2010 | pp. 265–268Open access
Aqueous Extract of Garcinia indica Choisy Restores Glutathione in Type 2 Diabetic Rats
- 1,
- 2
- 1 T.V.M. College of Pharmacy, Gandhinagar, Bellary-583103, Karnataka, INDIA.
- 2 Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Srinivasan BPDepartment of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi, INDIA. Email: bpsrinivasan@yahoo.com
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 18, 2010
How to cite
H, K., & BP, S. (2010). Aqueous Extract of Garcinia indica Choisy Restores Glutathione in Type 2 Diabetic Rats. Journal of Young Pharmacists, 2(3), 265–268. https://doi.org/10.4103/0975-1483.66806
Abstract
Significant depletion of glutathione (GSH-reduced form) was observed in type 2 diabetes due to oxidative stress. Hence the present study was aimed to investigate a drug which restores GSH along with its anti-diabetic activity. Aqueous extract of Garcinia indica at a dose of 100 mg/kg and 200 mg/kg was given orally to streptozotocininduced type 2 diabetic rats for a period of 4 weeks. At the end, parameters such as fasting blood glucose, postprandial blood glucose, and GSH in blood were analyzed. Aqueous extract of G. indica significantly decreased both the fasting and postprandial blood glucose in type 2 diabetic rats. The extract also restored the erythrocyte GSH in type 2 diabetic rats. Drug at higher dose, i.e. 200 mg/kg, had a more pronounced effect. Restoring the erythrocyte GSH, an intracellular anti-oxidant in diabetes, will be beneficial specially by preventing the risk of developing complications.
Keywords
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Article metadata
| Title | Aqueous Extract of Garcinia indica Choisy Restores Glutathione in Type 2 Diabetic Rats |
|---|---|
| Authors | Kirana H; Srinivasan BP |
| Affiliations | T.V.M. College of Pharmacy, Gandhinagar, Bellary-583103, Karnataka, INDIA.; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), M.B. Road, Sector-III, Pushp Vihar, New Delhi, INDIA. |
| Corresponding author | bpsrinivasan@yahoo.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 2, Issue 3 (2010) |
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