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Pharm ChemistryJournal of Young PharmacistsVol. 2 | Issue 4 | 2010 | pp. 399–402Open access
Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines
- 1,
- 2*,
- 3,
- 4
- 1 Department of Chemistry, Islamic Azad University, Young Researchers Club, IRAN.
- 2 Department of Chemistry, IRAN.
- 3 Medicinal Sciences, Islamic Azad University, IRAN.
- 4 Moravvej Student-Research Institute, Ardabil Branch, Ardabil, IRAN.
Published in Journal of Young Pharmacists
Correspondence: Ghammamy S
Department of Chemistry, IRAN.
Email: shghamami@ikiu.ac.ir or
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Oct 15, 2010
How to cite
F, S., S, G., A, J., & F, S. (2010). Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines. Journal of Young Pharmacists, 2(4), 399–402. https://doi.org/10.4103/0975-1483.71638
Abstract
Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4-[(E)-2-phenylethylidene] (NPI), N4[(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N4[(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).
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Article metadata
| Title | Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4[(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines |
|---|---|
| Authors | Shabani F; Ghammamy S; Jahazi A; Siavoshifar F |
| Affiliations | Department of Chemistry, Islamic Azad University, Young Researchers Club, IRAN.; Department of Chemistry, IRAN.; Medicinal Sciences, Islamic Azad University, IRAN.; Moravvej Student-Research Institute, Ardabil Branch, Ardabil, IRAN. |
| Corresponding author | shghamami@ikiu.ac.ir or |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 2, Issue 4 (2010) |
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