Open access · Peer reviewed · No APCs
Pharm AnalysisJournal of Young PharmacistsVol. 2 | Issue 4 | 2010 | pp. 410–413Open access
A Simple RP-HPLC Method for Quantitation of Itopride HCl in Tablet Dosage Form
- 1*,
- 2,
- 3,
- 3,
- 3,
- 3
- 1 Departments of Pharmaceutical Analysis, INDIA.
- 2 Pharmacology, INDIA.
- 3 Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Thiruvengada Rajan VS
Departments of Pharmaceutical Analysis, INDIA.
Email: rajan_pharma2000@yahoo.co.in
Copyright: © 2010 Manuscript Technomedia. This is an open access article.
- Published:
- Oct 15, 2010
How to cite
VS, T. R., TS, M. S., S, R., M, A., K, G., & 3, M. C. (2010). A Simple RP-HPLC Method for Quantitation of Itopride HCl in Tablet Dosage Form. Journal of Young Pharmacists, 2(4), 410–413. https://doi.org/10.4103/0975-1483.71634
Abstract
An isocratic reversed phase high-performance liquid chromatographic method with ultraviolet detection at 220 nm has been developed for the quantification of itopride hydrochloride in tablet dosage form. The quantification was carried out using C8 column (250 mm × 4.6 mm), 5-μm particle size SS column. The mobile phase comprised of two solvents (Solvent A: buffer 1.4 mL ortho-phosphoric acid adjusted to pH 3.0 with triethyl amine and Solvent B: acetonitrile). The ratio of Solvent A: Solvent B was 75:25 v/v. The flow rate was 1.0 mL-1 with UV detection at 220 nm. The method has been validated and proved to be robust. The calibration curve was linear in the concentration range of 80-120% with coefficient of correlation 0.9995. The percentage recovery for itopride HCl was 100.01%. The proposed method was validated for its selectivity, linearity, accuracy, and precision. The method was found to be suitable for the quality control of itopride HCl in tablet dosage formulation.
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Article metadata
| Title | A Simple RP-HPLC Method for Quantitation of Itopride HCl in Tablet Dosage Form |
|---|---|
| Authors | Thiruvengada Rajan VS; Mohamed Saleem TS; Ramkanth S; Alagusundaram M; Ganaprakash K; Madhusudhana Chetty 3 |
| Affiliations | Departments of Pharmaceutical Analysis, INDIA.; Pharmacology, INDIA.; Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, INDIA. |
| Corresponding author | rajan_pharma2000@yahoo.co.in |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 2, Issue 4 (2010) |
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