Open access · Peer reviewed · No APCs
PharmaceuticsJournal of Young PharmacistsVol. 4 | Issue 1 | 2012 | pp. 13–16Open access
Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen
- 1*,
- 2,
- 3,
- 4,
- 5,
- 6
- 1 Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.
- 2 Pharmaceutics, INDIA.
- 3 Pharmacology, Rajendra Institute of Technology and Sciences, Sirsa, Haryana, INDIA.
- 4 Pharmaceutics, M. D. University, Rohtak, INDIA.
- 5 Pharmaceutical Chemistry, Malwa College of Pharmacy, Bhatinda, Punjab, INDIA.
- 6 Pharmaceutics, NCRD Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, INDIA.
Published in Journal of Young Pharmacists
Correspondence: Nagpal M
Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.
Email: nagpalmanju@ymail.com
Copyright: © 2012 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 18, 2012
How to cite
M, N., DK, M., P, R., H, D., S, G., & G, D. (2012). Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen. Journal of Young Pharmacists, 4(1), 13–16. https://doi.org/10.4103/0975-1483.93573
Abstract
The present study was designed to investigate the effects of different variables on the release profile of ibuprofen microspheres formulated using modified emulsification method. Eight batches of microspheres (F1–F8) were prepared by applying 2³ factorial design. The amount of sodium alginate, amount of calcium chloride, and amount of magnesium stearate were selected as formulation variables. All the batches were evaluated in terms of percentage yield, percentage encapsulation efficiency and in vitro release characteristics. The batch F7 was found to be optimum batch and was further characterized via scanning electron microscopy (SEM) and particle size analysis. Multiple linear regression was applied to confirm significant effect of each variable on release characteristics. The model developed in the present study can be effectively utilized to achieve the formulation with desired release characteristics.
Keywords
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Article metadata
| Title | Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen |
|---|---|
| Authors | Nagpal M; Maheshwari DK; Rakha P; Dureja H; Goyal S; DhingraDhingra G |
| Affiliations | Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.; Pharmaceutics, INDIA.; Pharmacology, Rajendra Institute of Technology and Sciences, Sirsa, Haryana, INDIA.; Pharmaceutics, M. D. University, Rohtak, INDIA.; Pharmaceutical Chemistry, Malwa College of Pharmacy, Bhatinda, Punjab, INDIA.; Pharmaceutics, NCRD Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, INDIA. |
| Corresponding author | nagpalmanju@ymail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 4, Issue 1 (2012) |
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