Open access · Peer reviewed · No APCs
PharmacologyJournal of Young PharmacistsVol. 4 | Issue 2 | 2012 | pp. 78–81Open access
Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats
- 1,
- 1*,
- 1,
- 1
- 1 Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NIGERIA.
Published in Journal of Young Pharmacists
Correspondence: Akhigbe RE
Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NIGERIA.
Email: akhigbemcroy@yahoo.com
Copyright: © 2012 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 22, 2012
How to cite
WA, S., RE, A., OT, P., & OS, O. (2012). Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats. Journal of Young Pharmacists, 4(2), 78–81. https://doi.org/10.4103/0975-1483.96620
Abstract
This study was carried out to investigate the effect of Aloe vera extract (AvE) on serum electrolytes, urea, and creatinine as indices of renal function in Sprague-Dawley rats. Twelve male Sprague-Dawley rats weighing between 80 and 130 g were used. Rats were divided into two groups: The control and the test groups (n=6). The test group received 1 ml of AvE daily for 28 days. Both the groups fed on standard rat chow and water ad libitum. The results showed a decrease in serum levels of sodium, and potassium, but an increase in the serum levels of bicarbonate, urea, and creatinine in the test group. The changes seen were, however, statistically insignificant, except for the serum levels of sodium and creatinine (P<0.05). It is thus concluded that AvE impairs renal handling of electrolytes with consequent hyponatremia and hypercreatinemia. However, this might be of therapeutic value in conditions associated with hypernatremia.
Keywords
Subject
Article metadata
| Title | Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats |
|---|---|
| Authors | Saka WA; Akhigbe RE; Popoola OT; Oyekunle OS |
| Affiliations | Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NIGERIA. |
| Corresponding author | akhigbemcroy@yahoo.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 4, Issue 2 (2012) |
Also in this issue
- Outgoing Editor’s Messagepp. 65
- A Novel Extraction Method and Some Physicochemical Properties of Extractives of Irvingia Gabonensis Seedspp. 66–72
- Diuretic Effects of Cleistanthin A and Cleistanthin B from the Leaves of Cleistanthus Collinus in Wistar Ratspp. 73–77
- Antitumor, Analgesic, and Anti-inammatory Activities of Synthesized Pyrazolinespp. 82–87
- Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Techniquepp. 88–94
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026