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Short communicationJournal of Young PharmacistsVol. 5 | Issue 4 | 2013 | pp. 188–190Open access
Herbs in association with drugs: Enhancement of the aminoglycosideantibiotic activity by Pityrogramma calomelanos (L.) Link
- 1,
- 1,
- 2,
- 3,
- 4,
- 1*
- 1 Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, University of the Region of Cariri, CE/Crato, CE, BRAZIL.
- 2 Laboratory of Natural Products Research, Department of Biological Chemistry, University of the Region of Cariri, CE/Crato, BRAZIL.
- 3 Laboratory of Paleontology, Department of Biological Sciences, University of the Region of Cariri, CE/Crato, BRAZIL.
- 4 Laboratory of Biochemistry and Cellular Biology, Department of Ecology and Environment, Federal University of Paraiba, PB/Rio Tinto, BRAZIL.
Published in Journal of Young Pharmacists
Correspondence: Henrique D.M. Coutinho
Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, University of the Region of Cariri, CE/Crato, CE, BRAZIL.
Email: hmcoutinho@urca.br
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Dec 12, 2013
- Received:
- Aug 25, 2013
- Accepted:
- Oct 19, 2013
How to cite
Souza, T. M., Morais-Braga, M. F., Costa, J. G., Saraiva, A. A., Lima, M. A., & Coutinho, H. D. (2013). Herbs in association with drugs: Enhancement of the aminoglycosideantibiotic activity by Pityrogramma calomelanos (L.) Link. Journal of Young Pharmacists, 5(4), 188–190. https://doi.org/10.1016/j.jyp.2013.10.004
Abstract
Aims: In this work, the ethyl acetate and hexane fractions of Pityrogramma calomelanos (L.) were evaluated to antibacterial and antifungal activity against strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Candida krusei and Candida tropicalis. Methods: The study was performed aiming to assess the antimicrobial effect with the method of dilution in HIA. The hexane and ethyl acetate fractions were named HFPC and EAFPC, respectively. Results: Both fractions of specie P. calomelanos displayed good activity against S. aureus when associated with gentamicin. When associated with the antifungal, the fractions did not exhibit relevant activity against species of Candida. Conclusions: These results indicate that this specie can be used as a possible source of natural products of antibacterial interest, mainly when combined with aminoglycosides.
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Article metadata
| Title | Herbs in association with drugs: Enhancement of the aminoglycosideantibiotic activity by Pityrogramma calomelanos (L.) Link |
|---|---|
| Authors | Teógenes M. Souza; Maria F.B. Morais-Braga; José G.M. Costa; Antônio A.F. Saraiva; Micheline A. Lima; Henrique D.M. Coutinho |
| Affiliations | Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, University of the Region of Cariri, CE/Crato, CE, BRAZIL.; Laboratory of Natural Products Research, Department of Biological Chemistry, University of the Region of Cariri, CE/Crato, BRAZIL.; Laboratory of Paleontology, Department of Biological Sciences, University of the Region of Cariri, CE/Crato, BRAZIL.; Laboratory of Biochemistry and Cellular Biology, Department of Ecology and Environment, Federal University of Paraiba, PB/Rio Tinto, BRAZIL. |
| Corresponding author | hmcoutinho@urca.br |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 5, Issue 4 (2013) |
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