Acute renal damage in Acetaminophen poisoning

Acetaminophen is one of the most commonly used analgesic globally. It is first-line pharmacologic agent for the symptomatic treatment of mild to moderate pain recommended by WHO. Acetaminophen may act as a potent hepatotoxic and it is account for 5% of drug poisonings cases, being a frequent cause of acute liver failure.1 It is still little-known fact that acetaminophen poisoning can cause kidney injury, especially for those pharmacist who are at an early stage of clinical pharmacy career. Therefore this prompt us to provide two interesting cases of acetaminophen poisining with renal manifestions in which clinical pharmacists were active members of the care team.