Open access · Peer reviewed · No APCs
Short communicationJournal of Young PharmacistsVol. 9 | Issue 2 | 2017 | pp. 296–298Open access
In vivo Study of Tetraprenyltoluquinone, An Anticancer Compounds from Garcinia cowa Roxb
- 1*,
- 2,
- 3,
- 4,
- 1
- 1 Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, INDONESIA.
- 2 CARIF (Cancer Research Institute Foundation) , MALAYSIA.
- 3 Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, MALAYSIA.
- 4 Laboratory of Natural Products, Institut of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, MALAYSIA.
Published in Journal of Young Pharmacists
Correspondence: Fatma Sri Wahyuni
Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, INDONESIA.
Email: fatmasriwahyuni@gmail.com
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 23, 2017
- Received:
- Nov 7, 2016
- Accepted:
- Dec 28, 2016
How to cite
Wahyuni, F. S., Hui, L. S., Stanslas, J., Lajis, N. H., & d, D. (2017). In vivo Study of Tetraprenyltoluquinone, An Anticancer Compounds from Garcinia cowa Roxb. Journal of Young Pharmacists, 9(2), 296–298. https://doi.org/10.5530/jyp.2017.9.58
Abstract
Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicle treated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.
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Subject
Article metadata
| Title | In vivo Study of Tetraprenyltoluquinone, An Anticancer Compounds from Garcinia cowa Roxb |
|---|---|
| Authors | Fatma Sri Wahyuni; Lim Siang Hui; Johnson Stanslas; Nordin Hj Lajis; Dachriyanus d |
| Affiliations | Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, INDONESIA.; CARIF (Cancer Research Institute Foundation) , MALAYSIA.; Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 43400 UPM, Serdang, Selangor, MALAYSIA.; Laboratory of Natural Products, Institut of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, MALAYSIA. |
| Corresponding author | fatmasriwahyuni@gmail.com |
| Journal | Journal of Young Pharmacists |
| Volume / Issue | Vol. 9, Issue 2 (2017) |
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