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Research ArticlePharmacognosy CommunicationsVol. 4 | Issue 3 | 2014 | pp. 56–61Open access
Pharmacological Effects of Peganum Harmala L. Root Extract on Isolated Rat small Intestine
- 1,
- 2*,
- 3,
- 4,
- 1 Dept. of Anatomy and Histology, Faculty of Medicine, The University of Jordan, JORDAN.
- 2 Dept. of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, JORDAN.
- 3 Dept. of Physiology and Biochemistry, Faculty of Medicine, The University of Jordan, JORDAN.
- 4 Dept. of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, JORDAN.
Published in Pharmacognosy Communications
Correspondence: Abuhamdah S
Dept. of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, JORDAN.
Email: smaabuhamdah@gmail.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- May 18, 2014
- DOI:
- 10.5530/pc.2014.3.6
How to cite
A, S., S, A., M, A. E., F, M., & S, A. O. (2014). Pharmacological Effects of Peganum Harmala L. Root Extract on Isolated Rat small Intestine. Pharmacognosy Communications, 4(3), 56–61. https://doi.org/10.5530/pc.2014.3.6
Abstract
Background: Peganum harmala L. is a medicinal plant used in Jordan and in many countries in traditional medicine against several diseases, including gastrointestinal disorders. Objective: In this study, the effects of crude ethanolic root extract of P. harmala on the isolated smooth muscle of the rat jejunum intestine were investigated. Materials and Methods: The isolated organ bath method was adopted. The efficacy was recorded and analyzed by biological signal collection and analysis recording. Results: The ethanolic root extract inhibited the spontaneous contraction of rat jejunum and showed dose dependent inhibition of acetylcholine Ach (10–5 m) and potassium chloride KCl (60 mm), as well as inducing contractions of isolated rat jejunum. The extract also reduced barium chloride BaCl2 (5 mm) induced contractions of isolated rat jejunum dose-dependently. The inhibitions were statistically significant. Conclusion: These results indicated that the root extract of P. harmala possesses antispasmodic activity and justifies its use traditionally in alleviating gastrointestinal disorders.
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Article metadata
| Title | Pharmacological Effects of Peganum Harmala L. Root Extract on Isolated Rat small Intestine |
|---|---|
| Authors | Shatarat A; Abuhamdah S; Al-Essa M; Mohammed F; Al-Olimat S |
| Affiliations | Dept. of Anatomy and Histology, Faculty of Medicine, The University of Jordan, JORDAN.; Dept. of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, JORDAN.; Dept. of Physiology and Biochemistry, Faculty of Medicine, The University of Jordan, JORDAN.; Dept. of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, JORDAN. |
| Corresponding author | smaabuhamdah@gmail.com |
| Journal | Pharmacognosy Communications |
| Volume / Issue | Vol. 4, Issue 3 (2014) |
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