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Research ArticlePharmacognosy ResearchVol. 1 | Issue 2 | 2009 | pp. 43–52Open access
Antifouling Alkaloids from Crinum augustum (Amaryllidaceae)
- 1,
- 1*,
- 1,
- 2,
- 2,
- 3,
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- 1 Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
- 2 Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.
- 3 Faculty of environmental earth science, Hokkaido University, Sapporo, 060-0810, Japan
- 4 Central Research Institute of Electric Power Industry, Biology Department, 1646 Abiko, Chiba 270-1194 Japan
Published in Pharmacognosy Research
Correspondence: Ahmed Abdel-Lateff
Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
Email: aabelazim@yahoo.co.uk
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2009
- Received:
- Jan 2, 2009
- Accepted:
- Jun 22, 2009
How to cite
Refaat, J., Abdel-Lateff, A., Kamel, M. S., Ali, A. A., Ramadan, M. A., Okino, T., & Nogata, Y. (2009). Antifouling Alkaloids from Crinum augustum (Amaryllidaceae). Pharmacognosy Research, 1(2), 43–52.
Abstract
Fractionation and purification of the ethanolic extract of the bulbs of Crinum augustum Rox. (Amaryllidaceae) cultivated in Egypt yielded five alkaloids 6-methoxy-crinamine (1), crinamine (2), buphanisine (3), ungeremine (4), and hippadine (5); two fatty acid derivatives: myristic acid ethyl ester (6) and palmitic acid ethyl ester (7); four terpenoidal and steroidal compounds: ursolic acid (8), β-sitosterol-O- β glucopyranoside (9) and mixture of β- sitosterol (10) and stigmasterol (11). The structures of all compounds were determined by interpretation of their spectroscopic data; 1D (1H and 13C), 2D (HSQC, COSY, DQF, NOE and HMBC) NMR; MS and UV analyses. The compounds (1-4) and (6-8) were tested towards biofouling activity using larvae of barnacle Balance amphitrie. Significant activities of 1, 2 and 3 with EC50 1.8, 1.2 and 0.75 µg/mL respectively, were observed.
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Article metadata
| Title | Antifouling Alkaloids from Crinum augustum (Amaryllidaceae) |
|---|---|
| Authors | John Refaat; Ahmed Abdel-Lateff; Mohamed S. Kamel; Ahmed A. Ali; Mahmoud A. Ramadan; Tatsufumi Okino; Yasuyuki Nogata |
| Affiliations | Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.; Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.; Faculty of environmental earth science, Hokkaido University, Sapporo, 060-0810, Japan; Central Research Institute of Electric Power Industry, Biology Department, 1646 Abiko, Chiba 270-1194 Japan |
| Corresponding author | aabelazim@yahoo.co.uk |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 1, Issue 2 (2009) |
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