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Research ArticlePharmacognosy ResearchVol. 1 | Issue 5 | 2009 | pp. 274–279Open access
Anti-leukemia Activity of Methanolic Extracts of Lantana camara
- 1*,
- 1,
- 1,
- 2
- 1 Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia. Emails: srisasidharan@yahoo.com, jegathas@yahoo.com.
- 2 Centre for Drug Research, University Science of Malaysia, 11800 Minden, Pulau Pinang. Malaysia. Email: srama@usm.my
Published in Pharmacognosy Research
Correspondence: Badakhshan Mahdi Pour
Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia. Emails: srisasidharan@yahoo.com, jegathas@yahoo.com.
Email: mpbadakhshan@gmail.com
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2009
- Received:
- Jun 22, 2009
- Accepted:
- Aug 22, 2009
How to cite
Pour, B. M., Sasidharan, S., Jegathambigai, R. N., & Surash, R. (2009). Anti-leukemia Activity of Methanolic Extracts of Lantana camara. Pharmacognosy Research, 1(5), 274–279.
Abstract
Anticancer effect of Lantana camara’s root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 ± 53.08 μg/ml; leaf, 394.41 ± 99.73 μg/ml; p > 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 ± 3.60 μg/ml; p < 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara’s root and leaf extracts might be subjects for further fractionation and identification to find new anticancer agents.
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Article metadata
| Title | Anti-leukemia Activity of Methanolic Extracts of Lantana camara |
|---|---|
| Authors | Badakhshan Mahdi Pour; Sreenivasan Sasidharan; Rameshwar Naidu Jegathambigai; Ramanathan Surash |
| Affiliations | Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia. Emails: srisasidharan@yahoo.com, jegathas@yahoo.com.; Centre for Drug Research, University Science of Malaysia, 11800 Minden, Pulau Pinang. Malaysia. Email: srama@usm.my |
| Corresponding author | mpbadakhshan@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 1, Issue 5 (2009) |
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