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Research ArticlePharmacognosy ResearchVol. 1 | Issue 6 | 2009 | pp. 352–358Open access
Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic rats
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- 1 Department of Biochemistry, S.V.University, Tirupati-517502, AndhraPradesh, India.
Published in Pharmacognosy Research
Correspondence: Ch. Apparao
Department of Biochemistry, S.V.University, Tirupati-517502, AndhraPradesh, India.
Email: chippadar@yahoo.com
Copyright: © 2009 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2009
- Received:
- Aug 29, 2009
- Accepted:
- Sep 17, 2009
How to cite
Rajasekhar, M., Babu, K. R., Vinay, K., Sampath, M., Sameena, S., & Apparao, C. (2009). Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic rats. Pharmacognosy Research, 1(6), 352–358.
Abstract
The methanolic supernatant fraction (MSF) of the aqueous extract of Momordica cymbalaria fruits when given to streptozotocin (STZ) induced diabetic rats showed a significant reduction (65.9%, P<0.001) in fasting blood glucose levels at a dose of 0.5g/ kg.b.w. These results were compared to that of glibenclamide, an oral hypoglycemic agent. The active MSF exhibited a dose dependent scavenging activity against 2, 2-diphenly-1-picrylhydrazyl (DPPH) radicals and nitric oxide radicals with an IC50 value of 42.5 and 157.2μg/ml, respectively. Further, the MSF had relatively lower reducing power, compared to that of ascorbic acid. The total phenolic content of the fraction was found to be 132mg/gm of dry fraction. In conclusion, MSF possess antihyperglycemic and antioxidant properties, which could be due to the presence of steroidal glycosides or phenolic compounds.
Keywords
Subject
Article metadata
| Title | Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic rats |
|---|---|
| Authors | M.D. Rajasekhar; K. Ramesh Babu; K. Vinay; M.R. Sampath; S.K. Sameena; Ch. Apparao |
| Affiliations | Department of Biochemistry, S.V.University, Tirupati-517502, AndhraPradesh, India. |
| Corresponding author | chippadar@yahoo.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 1, Issue 6 (2009) |
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