Antihypertensive Effect of Methanol Leaf Extract of Azadirachta indica is Mediated through Suppression of Renal Caspase 3 Expressions on Nω‑Nitro‑L‑Arginine Methyl Ester Induced Hypertension

• Temidayo Olutayo Omobowale¹,
• Ademola Adetokunbo Oyagbemi^2*,
• Olumuyiwa Abiola Adejumobi¹,
• Fisayo Ugbor¹,
• Ebunoluwa Racheal Asenuga²,
• Temitayo Olabisi Ajibade²,
• Jeremiah Moyinoluwa Afolabi¹,
• Blessing Seun Ogunpolu¹,
• Olufunke Olubunmi Falayi³,
• Idayat Titilayo Gbadamos⁴,
• Olufunke Eunice Ola-Davies²,
• Adebowale Bernard Saba³,
• Anofi Ashafa⁵,
• Momoh Audu Yakubu⁶,
• Adeolu Alex Adedapo⁴,
• Oluwafemi Omoniyi Oguntibeju⁷

1. ¹ Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, NIGERIA.
2. ² Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, NIGERIA.
3. ³ Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, NIGERIA.
4. ⁴ Faculty of Natural and Agricultural Sciences, Qwaqwa Campus, University of the Free State, SOUTH AFRICA.
5. ⁵ Department of Botany, Faculty of Science, University of Ibadan, NIGERIA.
6. ⁶ Department of Environmental and Interdisciplinary Sciences, College of Science, Engineering and Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston, TX, USA.
7. ⁷ Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, SOUTH AFRICA.

Published in Pharmacognosy Research