Development and Assessment of Phytophospholipid Nanovesicular Systems for Treatment of Diabetic Neuropathy

Background: Diabetic neuropathy (DN) is the most prevalent and problematic consequence of diabetes mellitus, with the highest rates of morbidity and death, as well as a significant financial burden on diabetes treatment. Aside from commercially available formulations, substantial research on herbal-based natural therapies to treat hyperglycemia and related consequences is underway. Objectives: The major aim of the study was to use an ethosomal gel to improve transdermal penetration of Curcuma longa and Boswellia serrata and to overcome the challenges of low transdermal drug delivery permeability. Materials and Methods: Curcuma longa and Boswellia serrata loaded ethosomes were made using a cold process with various amounts of ethanol and soya lecithin, and were improved based on entrapment efficiency, vesicular size, and ex-vivo investigations. Results: The optimized ethosomal formulation was then put into a gel and evaluated. Ex-vivo tests were conducted with Curcuma longa and Boswellia serrata ethosomal gels, which were compared to plain gel. The ethosomal system produced vesicles with sizes ranging from 1 to 100 nm, a spherical, smooth surface, and a maximum entrapment efficiency of Ne9. A modified ethosomal system (Ne9) was introduced into the gel and studied further. Conclusion: According to the findings, the ethosomal gel has a lot of potential for transdermal Curcuma longa and Boswellia serrata administration.