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Original ArticlePharmacognosy ResearchVol. 18 | Issue 2 | 2026 | pp. 483–493Open access
Computational Analysis of 31 Selected Trigonella foenum-graecum (Fenugreek) Phytochemicals as Modulating Agents of Human Lutropin and Follicle Stimulating Hormone
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- 1 Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed to be University), Saveetha University, Thandalam, Chennai, Tamil Nadu, INDIA.
Published in Pharmacognosy Research
Correspondence: Radhakrishnan Narayanaswamy
Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed to be University), Saveetha University, Thandalam, Chennai, Tamil Nadu, INDIA.
Email: kishnanbio07@gmail.com
Copyright: © 2026 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 18, 2026
- Received:
- Sep 2, 2025
- Accepted:
- Dec 15, 2025
How to cite
Thirunavukarasu, V., Sachin, B. S., Das, B., & Narayanaswamy, R. (2026). Computational Analysis of 31 Selected Trigonella foenum-graecum (Fenugreek) Phytochemicals as Modulating Agents of Human Lutropin and Follicle Stimulating Hormone. Pharmacognosy Research, 18(2), 483–493. https://doi.org/10.5530/pres.20260167
Abstract
Background and Objectives
Trigonella foenum-graecum (Fenugreek) has well known for various pharmacological activities. In the current investigation, we aimed to study 31 chosen phytoconstituents of T. foenum-graecum (Fenugreek) as potent modulating agents of human lutropin subunit beta (hLH beta) and human Follicle Stimulating Hormone (hFSH) using docking method.
Materials and Methods
The 31 chosen constituents of T. foenum-graecum (Fenugreek) were studied on the docking behaviour of hLH beta and hFSH by using the Swiss dock method.
Results
The docking analysis showed that Graecunin (E) of T. foenum-graecum (Fenugreek) has exhibited the highest binding energy (-9.98 and -10.30 kcal/mol) with the hLH beta and hFSH respectively.
Conclusion
Thus, the current finding gives new in sight about the 31 selected ligands of T. foenum-graecum (Fenugreek) as potent modulating agents of human lutropin subunit beta (hLH beta) and human follicle stimulating hormone (hFSH), which will help in managing Polycystic Ovary Syndrome (PCOS) related disorders.
Keywords
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Article metadata
| Title | Computational Analysis of 31 Selected Trigonella foenum-graecum (Fenugreek) Phytochemicals as Modulating Agents of Human Lutropin and Follicle Stimulating Hormone |
|---|---|
| Authors | Vijayalakshmi Thirunavukarasu; B S Sachin; Biswajit Das; Radhakrishnan Narayanaswamy |
| Affiliations | Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed to be University), Saveetha University, Thandalam, Chennai, Tamil Nadu, INDIA. |
| Corresponding author | kishnanbio07@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 18, Issue 2 (2026) |
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