Medicated Kajal Ophthalmic Nanoparticulated Drug Delivery System

Background

Kajal has been used for ages as a cosmetic and to cure eye conditions in India. In order to improve therapeutic efficacy and ocular safety, we create a herbal medicated kajal with optimal extraction, formulation, and evaluation. Novel herbal medicated kajal and in situ gel formulation were developed using natural ingredients, with Areca catechu extract as the key active component. Important herbal components such Ghee, Bhimseni Camphor, Dry Coconut, Nutmeg, and Areca catechu nut were used in formulation.

Objectives

This current study shows the development of formulations, evaluation and determination of drug content in formulation.

Materials and Methods

Ethanolic extraction of dried Areca catechu by using cold maceration method was followed by formulation development. Carbon filaments prepared by using Ghee, Bhimseni Camphor, Dry Coconut, Nutmeg were collected, evaluated and used for preparation of kajal and in situ gel with Areca catechu. Developed kajal and in situ gels formulations were evaluated as per official guidelines.

Results

Collected carbon filaments were evaluated with different parameters. Prepared carbon show satisfactory flow properties and compatibility. Two formulations were developed with these carbon filaments. All QA/QC parameters of kajals and gels were performed as per official methods. Spectrophotometric analysis confirmed uniform drug content with high linearity (R²=0.998) across the tested range.

Conclusion

The kajal and in situ gel prepared with ghee and Areca catechu was found to be better in quality as compared to other formulations prepared with other herbal materials. Hence it can conclude that nanoparticulated ophthalmic formulation prepared from untapped drug were found to be stable and standardized.